Fused pyrimidine derivativesFused pyrimidine derivatives R 0515 Imidazopyrimidines, Potent Inhibitors of p38 MAP Kinase. -A novel series of imidazopyrimidines [e.g. (I), (II)] is discovered that potently inhibit p38 and suppress the production of TNF-α in vivo. -(RUPERT*, K. C.; HENRY, J. R.; DODD, J. H.; WADSWORTH, S. A.; CAVENDER, D. E.; OLINI, G. C.; FAHMY, B.; SIEKIERKA, J.
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