The results of our prospective study have revealed great diversity in the treatment regimens used to manage MM in real-life practice. This diversity was linked to factors such as novel agent accessibility and evolving treatment recommendations. Our results provide insight into associated clinical benefits.

In cases of contra-indication for high-dose chemotherapy for elderly patients with DLBCL, without complete remission, the Gemcitabine-based therapy protocol represents a more effective and less toxic than that of ESHAP.

Despite the availability of factor replacement to manage acute bleeding in haemophilia, haemarthrosis may occur due to delayed therapy or lack of detection, leading to joint damage. Orthopaedic surgery is one option to help improve patient quality of life. Assessment of current treatment patterns is required for physicians to optimize long-term management of patients; however, there are few studies available to determine the real-life situation in African/Middle-Eastern countries, such as Algeria. This was a multicentre, retrospective study of patients with haemophilia treated with on-demand factor replacement. Seven haematology centres in Algeria provided evaluable clinical data for 536 patients, including joint status and requirement for surgical intervention. Surgery was recommended in 326 (61%) patients (239 patients with severe haemophilia, 79 moderate and eight mild). Surgical procedures per patient age group were: 11 in patients ≤5 years, 34 in 6-10 years, 169 in 11-20 years, 183 in 21-30 years and 122 in ≥31 years. 14% of all procedures involved joint replacement, 56% other major surgeries and 30% minor surgeries (synoviorthesis). Minor surgery was most common in younger patients, while major surgeries increased proportionately with patient age. In Algeria, insufficient use of factor replacement has led to many patients with haemophilia experiencing haemarthrosis, leading to joint damage requiring surgery. This study aids assessment of the scale of the problem and identification of the surgical needs of patients. This may help plan targeted resourcing for patients most at risk of long-term disability and those likely to benefit from earlier surgical intervention.

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