NCT02319083.

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Adherence to the current guidelines on the early discontinuation of P2Y12 receptor antagonists is of utmost importance to reduce excessive bleeding and early mortality after CABG. Inter-institutional variation should be considered for a correct interpretation of the results in multicentre studies evaluating perioperative bleeding and use of blood products.

, et al.. Bleeding, transfusion and the risk of stroke after coronary surgery: A prospective cohort study of 2357 patients. International Journal of Surgery, Elsevier, 2016, 32, pp.50-57. 10.1016/j.ijsu.2016 M A N U S C R I P T Conclusions: Bleeding and blood transfusion are associated with an increased risk of stroke after CABG, which is highest in patients with severe bleeding. A C C E P T E D ACCEPTED MANUSCRIPT Bleeding, Transfusion and the Risk of Stroke after Coronary Surgery: Analysis of the E-CABG registry