In patients who had ulcer complications related to the long-term use of low-dose aspirin, treatment with lansoprazole in addition to the eradication of H. pylori infection significantly reduced the rate of recurrence of ulcer complications.
Gastric cancer is the world's second most common cause of cancer death. We
analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic
gastric cancers, and 22 nonneoplastic gastric tissues, using cDNA microarrays
representing ∼30,300 genes. Gastric cancers were distinguished from
nonneoplastic gastric tissues by characteristic differences in their gene
expression patterns. We found a diversity of gene expression patterns in
gastric cancer, reflecting variation in intrinsic properties of tumor and
normal cells and variation in the cellular composition of these complex
tissues. We identified several genes whose expression levels were
significantly correlated with patient survival. The variations in gene
expression patterns among cancers in different patients suggest differences in
pathogenetic pathways and potential therapeutic strategies
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