The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence.

The Giant Radio Array for Neutrino Detection (GRAND) 1 is a planned large-scale observatory of ultra-highenergy (UHE) cosmic particles -cosmic rays, gamma rays, and neutrinos with energies exceeding 10 8 GeV. Its ultimate goal is to solve the long-standing mystery of the origin of UHE cosmic rays. It will do so by detecting an unprecedented number of UHECRs and by looking with unmatched sensitivity for the undiscovered UHE neutrinos and gamma rays associated to them. Three key features of GRAND will make this possible: its large exposure at ultra-high energies, sub-degree angular resolution, and sensitivity to the unique signals made by UHE neutrinos.The strategy of GRAND is to detect the radio emission coming from large particle showers that develop in the terrestrial atmosphereextensive air showers -as a result of the interaction of UHE cosmic rays, gamma, rays, and neutrinos. To achieve this, GRAND will be the largest array of radio antennas ever built. The relative affordability of radio antennas makes the scale of construction possible. GRAND will build on years of progress in the field of radio-detection and apply the large body of technological, theoretical, and numerical advances, for the first time, to the radio-detection of air showers initiated by UHE neutrinos.The design of GRAND will be modular, consisting of several independent sub-arrays, each of 10 000 radio antennas deployed over 10 000 km 2 in radio-quiet locations. A staged construction plan ensures that key techniques are progressively validated, while simultaneously achieving important science goals in UHECR physics, radioastronomy, and cosmology early during construction.Already by 2025, using the first sub-array of 10 000 antennas, GRAND could discover the long-sought cosmogenic neutrinos -produced by interactions of ultra-high-energy cosmic-rays with cosmic photon fields -if their flux is as high as presently allowed, by reaching a sensitivity comparable to planned upgraded versions of existing experiments. By the 2030s, in its final configuration of 20 sub-arrays, GRAND will reach an unparalleled sensitivity to cosmogenic neutrino fluxes of 4 • 10 −10 GeV cm −2 s −1 sr −1 within 3 years of operation, which will guarantee their detection even if their flux is tiny. Because of its sub-degree angular resolution, GRAND will also search for point sources of UHE neutrinos, steady and transient, potentially starting UHE neutrino astronomy. Because of its access to ultra-high energies, GRAND will chart fundamental neutrino physics at these energies for the first time.GRAND will also be the largest detector of UHE cosmic rays and gamma rays. It will improve UHECR statistics at the highest energies ten-fold within a few years, and either discover UHE gamma rays or improve their limits ten-fold. Further, it will be a valuable tool in radioastronomy and cosmology, allowing for the discovery and follow-up of large numbers of radio transients -fast radio bursts, giant radio pulses -and for precise studies of the epoch of reionization.Following the disc...

After the completion of a draft human genome sequence, the International Human Genome Sequencing Consortium has proceeded to finish and annotate each of the 24 chromosomes comprising the human genome. Here we describe the sequencing and analysis of human chromosome 3, one of the largest human chromosomes. Chromosome 3 comprises just four contigs, one of which currently represents the longest unbroken stretch of finished DNA sequence known so far. The chromosome is remarkable in having the lowest rate of segmental duplication in the genome. It also includes a chemokine receptor gene cluster as well as numerous loci involved in multiple human cancers such as the gene encoding FHIT, which contains the most common constitutive fragile site in the genome, FRA3B. Using genomic sequence from chimpanzee and rhesus macaque, we were able to characterize the breakpoints defining a large pericentric inversion that occurred some time after the split of Homininae from Ponginae, and propose an evolutionary history of the inversion.

TREND50 is a radio detection setup of 50 self-triggered antennas working in the 50-100 MHz frequency range and deployed in a radio-quiet valley of the Tianshan mountains (China). TREND50 achieved its goal: the autonomous radiodetection and identification of air showers. Thanks to a dedicated offline selection algorithm, 564 air shower candidates were indeed selected out of 7 · 10 8 transient radio signals recorded during the 314 live days of data taken during the first two years of operation of this setup (2011 and 2012). This event rate, as well as the distribution of the candidate directions of arrival, is consistent with what is expected from cosmic-ray-induced air showers according to simulations, assuming an additional ∼20% contamination of the final sample by background events. This result is obtained at the cost of a reduced air shower detection efficiency, estimated to be ∼3%.ficiency is mostly due to the large amount of dead time of the setup. This result paves the way for the GRANDProto35 experiment, the first stage of the GRAND project.