LH is common in China and associated with worse glycemic control, despite nearly one-third greater insulin consumption, with large cost implications. Proper injection technique education may reduce LH prevalence.

We present the first results from the B-fields In STar-forming Region Observations (BISTRO) survey, using the Sub-millimetre Common-User Bolometer Array2 camera, with its associated polarimeter (POL-2), on the James Clerk Maxwell Telescope in Hawaii. We discuss the survey's aims and objectives. We describe the rationale behind the survey, and the questions thatthe survey will aim to answer. The most important of these is the role of magnetic fields in the star formation process on the scale of individual filaments and cores in dense regions. We describe the data acquisition and reduction processes for POL-2, demonstrating both repeatability and consistency with previous data. We present a first-look analysis of the first results from the BISTRO survey in the OMC1 region. We see that the magnetic field lies approximately perpendicular to the famous "integral filament" in the densest regions of that filament. Furthermore, we see an "hourglass" magnetic field morphology extending beyond the densest region of the integral filament into the less-dense surrounding material, and discuss possible causes for this. We also discuss the more complex morphology seen along the Orion Bar region. We examine the morphology of the field along the lower-density northeastern filament. We find consistency with previous theoretical models that predict magnetic fields lying parallel to low-density, non-self-gravitating filaments, and perpendicular to higher-density, self-gravitating filaments.

The ketone metabolite β-hydroxybutyrate (βOHB), is reported to be neuroprotective after spinal cord injury (SCI) in rats, but the underlying mechanism remains unknown. The present study aims to investigate effects of βOHB on suppression of oxidative stress and inhibition of class I histone deacetylases (HDACs) in in vivo and in vitro models. Rats were fed with ketogenic diet (KD) or standard diet (SD) for 3 weeks. A C5 hemi-contusion injury was applied to these animals on the 14th day of experiment, and spinal cord samples were harvested on the 1st, 3rd and 7th days after SCI, respectively. The blood ketone levels were significantly higher in the KD groups. KD reduced oxidative stress markers and reactive oxygen species (ROS) products, downregulated the expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX)2 and NOX4, and upregulated the expression of forkhead box group O (FOXO)3a, mitochondrial superoxide dismutase (MnSOD), and catalase after SCI. The in vitro study, performed on PC12 cells, indicated that βOHB inhibited HO-induced ROS production, decreased NOX2 and NOX4 protein levels, and upregulated FOXO3a, MnSOD, and catalase levels in a dose-dependent manner, which was consistent with the in vivo results. The ketone metabolite βOHB inhibited HDAC1, HDAC2, and HDAC3 activity, but not HDAC8 in SCI rats and PC12 cells. Depletion of HDAC1 or HDAC2 with small interfering RNA (siRNA) attenuated HO-induced ROS production and protein carbonylation and elevated FOXO3a protein levels, meanwhile reducing NOX2 and NOX4 protein expression in PC12 cells. Our results indicate that the ketone metabolite βOHB attenuates oxidative stress in SCI by inhibition of class I HDACs, and selected suppression of HDAC1 or HDAC2 regulates FOXO3a, NOX2, and NOX4 expression. Therefore, the ketone metabolite βOHB may be a novel promising therapeutic agent for SCI.

We present 850 µm imaging polarimetry data of the ρ Oph-A core taken with the Submillimeter Common-User Bolometer Array-2 (SCUBA-2) and its polarimeter (POL-2), as part of our ongoing survey project, BISTRO (Bfields In STar forming RegiOns). The polarization vectors are used to identify the orientation of the magnetic field projected on the plane of the sky at a resolution of 0.01 pc. We identify 10 subregions with distinct polarization fractions and angles in the 0.2 pc ρ Oph A core; some of them can be part of a coherent magnetic field structure in the ρ Oph region. The results are consistent with previous observations of the brightest regions of ρ Oph-A, where the degrees of polarization are at a level of a few percents, but our data reveal for the first time the magnetic field structures in the fainter regions surrounding the core where the degree of polarization is much higher (> 5%). A comparison with previous near-infrared polarimetric data shows that there are several magnetic field components which are consistent at near-infrared and submillimeter wavelengths. Using the Davis-Chandrasekhar-Fermi method, we also derive magnetic field strengths in several sub-core regions, which range from approximately 0.2 to 5 mG. We also find a correlation between the magnetic field orientations projected on the sky with the core centroid velocity components.