Chicago Classification v4.0 (CCv4.0) is the updated classification scheme for esophageal motility disorders using metrics from high‐resolution manometry (HRM). Fifty‐two diverse international experts separated into seven working subgroups utilized formal validated methodologies over two‐years to develop CCv4.0. Key updates in CCv.4.0 consist of a more rigorous and expansive HRM protocol that incorporates supine and upright test positions as well as provocative testing, a refined definition of esophagogastric junction (EGJ) outflow obstruction (EGJOO), more stringent diagnostic criteria for ineffective esophageal motility and description of baseline EGJ metrics. Further, the CCv4.0 sought to define motility disorder diagnoses as conclusive and inconclusive based on associated symptoms, and findings on provocative testing as well as supportive testing with barium esophagram with tablet and/or functional lumen imaging probe. These changes attempt to minimize ambiguity in prior iterations of Chicago Classification and provide more standardized and rigorous criteria for patterns of disorders of peristalsis and obstruction at the EGJ.

We have found that the addition of Cu to an FePt alloy film is an effective approach for reducing the ordering temperature of FePt. The coercivity of the FePtCu film is around 5 kOe after annealing at 300 °C, whereas that of FePt shows several hundred Oe. In the FePtCu film annealed at 700 °C, the coercivity is almost the same as for the FePt films. Therefore, the FePtCu film displays a hard-magnetic property similar to that of the FePt film. The results of x-ray diffraction indicate that a ternary FePtCu alloy is formed. Thus, the formation of the ternary FePtCu alloy is considered to play an important role in reducing the ordering temperature.

Colonic diverticulosis and diverticular bleeding are prevalent and increasing in Japan. Given the significant association of age with this trend, both diseases can be expected to increase for decades to come.

We developed and validated a scoring system for risk of severe LGIB based on 8 factors (NOBLADS score). The system also determined the risk for blood transfusion, longer hospital stay, and intervention. It might be used in decision making regarding intervention and management.

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