A rapid, facile and selective detection of anti-H5 subtype avian influenza virus (AIV) antibody in serum by fluorescence polarization immunoassay (FPIA) was achieved. A fragment of recombinant H5 subtype AIV hemagglutinin was produced and labeled with fluorescein to use it as a labeled antigen in FPIA. This labeled antigen was mixed with anti-AIV sera (H1-H16 subtypes) and FP of the mixture was measured using a portable FP analyzer on a microdevice. It was found that FP increased in proportion to the concentration of anti-H5 AIV antibody (serum) and was significantly higher than FP obtained with the other sera. The selective detection of anti-H5 subtype AIV antibody was confirmed. The required volume of original sample was 2 μL and analysis time was within 20 min. This detection system realizes an efficient on-site diagnosis and surveillance of AIV.

A novel color electrophoretic E-Paper using independently movable colored particles with different threshold fields was proposed for the first time. An a-Si TFT driven two primary colors prototype with red and cyan particles was successfully demonstrated. A full color feasibility was also proved using three primary colored particles (yellow, magenta and cyan), which showed a gamut as wide as that of newsprint.

A portable fluorescence polarization imaging analyzer was developed for high-throughput fluorescence polarization immunoassay.

An electrostatic tactile display with a projected capacitive touchscreen integrated into a single panel was demonstrated. Every electrode on the panel is driven for both tactile presentation and the touch sensor. The functions are both time and spatially multiplexed, and a reference-node-driven high-pass filter in the touch controller filters out the noise from the tactile driving signals.

Fluorescent polarization immunoassay (FPIA) is a single-step immunoassay method that is applicable to point-of-care testing; however, its applicability to large biomolecules has been restricted because ordinary FPIA is a competitive assay. Here, we report a noncompetitive FPIA using the variable domain from the heavy chain of a camelid antibody (VHH antibody). FPIA with VHH was successfully used to quantitate rabbit immunoglobulin G (IgG) and demonstrated a wider response range than that observed with antibody-binding (Fab) fragment. Then, using a portable FPIA instrument, a VHH-based immunoassay of human IgG in a human serum certified reference material was demonstrated.