The purpose of the study is to develop approaches to improve the health protection strategy of the nuclear industry enterprise staff and population living within its catchment area in the context of the national project “Healthcare”. The material for the study was information on dynamics in population indicators characterizing health status of the nuclear industry enterprise staff and population living within its catchment area in 1970-2017. Results. The study shows that the analyzed population is characterized by a significant decrease in the birth rate, increased mortality (including people of working age) from diseases of the circulatory system, malignant neoplasms and external causes, population decline, and decreased life expectancy. Conclusion. On the basis of the results obtained, approaches have been developed to improve health protection strategy for the above contingents in the context of the National Project “Healthcare”.

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Purpose: Development of the basic directions of a modern strategy for protecting the health of the adult population living in the activity zone of nuclear industry enterprises (using the example of the Seversk population). Material and methods: The object of the study was the population of the city of Seversk, formed around the Siberian Group of Chemical Enterprises. The subject of the study was demographic indicators; disability; incidence of malignant neoplasms, diseases of the circulatory system, injuries and accidents); socio-economic, behavioral and technological risk factors affecting the occurrence of major diseases. Results: It was established that by the end of the study period (1970–2017), the studied population was in a state of natural population decline due to a decrease in the birth rate and an increase in mortality, while the mortality rate exceeded the birth rate. During the period under review, the primary incidence of malignant neoplasia significantly increased; at the same time, the incidence of cardiovascular diseases, as well as the frequency of injuries and poisoning, decreased. Among the adult population of Seversk, behavioral factors (the habit of smoking, regular use of alcohol, a sedentary lifestyle, lack of regular physical activity) are more common than socio-economic (living conditions, financial situation) risk factors. Important risk factors are incorrect assessment by citizens of their own health and the reasons for its violation. Among Siberian Group of Chemical Enterprises workers exposed to tekhnogenic risk factor (long-term occupational exposure), there is an increased risk of cancer death of all localizations taken together, respiratory and digestive organs; bones, joints, mesothelium, soft tissues and genitals. At the same time, the risk of oncological mortality during irradiation was not exceeded in the range of small doses of (up to 100 mSv), and for any of the localization of malignant neoplasms this effect is not dose-dependent. Conclusion: The data obtained made it possible to specify and substantiate the basic directions of the modern strategy for protecting the health of the adult population living in the activity zone of nuclear industry enterprises (using the example of the Seversk population).

Purpose: To conduct genome wide association study of the association of 750,000 SNPs and an increased frequency of different types of chromosomal aberrations, induced by chronic irradiation in the dose range of 100–300 mSv. Material and methods: The study was conducted among Siberian Group of Chemical Enterprises healthy employees (n = 37) exposed to professional external γ-radiation in a dose range of 100–300 mSv. The de novo induced CNVs were previously detected in these persons. Mean dose – 188.8 ± 8.3 mSv, median – 185 mSv, interquartile range – 147.8–218.7 mSv, min – 103.4 mSv, max – 295.8 mSv. Genotyping of DNA samples from 37 employees was carried out by microarray CytoScan™ HD Array (Affymetrix, USA), containing 750,000 SNP-markers of 36,000 genes. The standard cytogenetic analysis was performed in the entire examined group. Results: We analyzed the association of these SNPs with the frequencies of aberrant cells and following chromosomal aberrations: single chromatid fragments, chromatid exchanges, paired fragments, dicentrics, rings, and translocations. We have found that 8 SNPs (rs10779468, rs158735, rs158710, rs158712, rs11131536, rs528170, rs9533572, rs10512439) are associated with the frequency of aberrant cells. Conclusion: We have discovered polymorphic variants that are associated with an increased frequency of aberrant cells in workers of Siberian Group of Chemical Enterprises exposed to irradiation at a dose of 100–300 mSv. This polymorphic variants can be considered as potential markers of individual radiosensitivity. To confirm identified associations, further validation studies on an extended sample of people exposed to radiation are needed.