In this review, we overview the main features and functions of NK cells, focusing on their role in cell-mediated immune response to tumor cells. In parallel, we discuss the information available in the field of NK cell receptors and offer a wide general overview of functional aspects of cell targeting and killing, focusing on the recent acknowledgments on the efficacy of NK cells after cytokine and mAb administration in cancer therapy. Since efficacy of NK cell-based immunotherapy has been proven in KIR-mismatch regimens or in TRAIL-dependent apoptosis, the ability to manipulate the balance of activating and inhibitory receptors on NK cells and of their cognate ligands, as well as the sensitivity of tumor cells to apoptosis, opens new perspectives for NK cell-based immunotherapy.

Overview of C-2 field-reversed configuration experiment plasma diagnosticsa) Rev. Sci. Instrum. 85, 11D836 (2014); 10.1063/1.4884616 Density fluctuation measurements by far-forward collective scattering in the MST reversed-field pincha) Rev. Sci. Instrum. 83, 10E302 (2012);A new high performance field reversed configuration operating regime in the C-2 devicea)Conventional field-reversed configurations (FRCs), high-beta, prolate compact toroids embedded in poloidal magnetic fields, face notable stability and confinement concerns. These can be ameliorated by various control techniques, such as introducing a significant fast ion population. Indeed, adding neutral beam injection into the FRC over the past half-decade has contributed to striking improvements in confinement and stability. Further, the addition of electrically biased plasma guns at the ends, magnetic end plugs, and advanced surface conditioning led to dramatic reductions in turbulence-driven losses and greatly improved stability. Together, these enabled the build-up of a well-confined and dominant fast-ion population. Under such conditions, highly reproducible, macroscopically stable hot FRCs (with total plasma temperature of $1 keV) with record lifetimes were achieved. These accomplishments point to the prospect of advanced, beam-driven FRCs as an intriguing path toward fusion reactors. This paper reviews key results and presents context for further interpretation. V C 2015 AIP Publishing LLC. [http://dx.

A hot stable field-reversed configuration (FRC) has been produced in the C-2 experiment by colliding and merging two high-β plasmoids preformed by the dynamic version of field-reversed θ-pinch technology. The merging process exhibits the highest poloidal flux amplification obtained in a magnetic confinement system (over tenfold increase). Most of the kinetic energy is converted into thermal energy with total temperature (T{i}+T{e}) exceeding 0.5 keV. The final FRC state exhibits a record FRC lifetime with flux confinement approaching classical values. These findings should have significant implications for fusion research and the physics of magnetic reconnection.

Tri Alpha Energy's experimental program has demonstrated reliable field-reversed configuration (FRC) formation and sustainment, driven by fast ions via high-power neutral-beam (NB) injection. The world's largest compact-toroid device, C-2U, was upgraded from C-2 with the following key system upgrades: increased total NB input power from ~4 MW (20 keV hydrogen) to 10+ MW (15 keV hydrogen) with tilted injection angle; enhanced edge-biasing capability inside of each end divertor for boundary/stability control. C-2U experiments with those upgraded systems have successfully demonstrated dramatic improvements in FRC performance and achieved sustainment of advanced beam-driven FRCs with a macroscopically stable and hot plasma state for up to 5+ ms. Plasma diamagnetism in the best discharges has reached record lifetimes of over 11 ms, timescales twice as long as C-2. The C-2U plasma performance, including the sustainment feature, has a strong correlation with NB pulse duration, with the diamagnetism persisting even several milliseconds after NB termination due to the accumulated fast-ion population by NB injection. Power balance analysis shows substantial improvements in equilibrium and transport parameters, whereby electron energy confinement time strongly correlates with electron temperature; i.e. the confinement time in C-2U scales strongly with a positive power of T e .

TAE Technologies' research is devoted to producing high temperature, stable, long-lived field-reversed configuration (FRC) plasmas by neutral-beam injection (NBI) and edge biasing/control. The newly constructed C-2W experimental device (also called "Norman") is the world's largest compact-toroid (CT) device, which has several key upgrades from the preceding C-2U device such as higher input power and longer pulse duration of the NBI system as well as installation of inner divertors with upgraded electrode biasing systems. Initial C-2W experiments have successfully demonstrated a robust FRC formation as well as its translation into the confinement vessel through the newly installed inner divertor with adequate guide magnetic field. They also produced dramatically improved initial FRC parameters with higher plasma temperatures (Te up to 300 eV; total electron and ion temperature >1.5 keV) and more trapped flux (up to ~15 mWb, based on rigid-rotor model) inside the FRC immediately after the merger of collided two CTs in the confinement section. As for effective edge biasing/control on FRC stabilization, a number of edge biasing schemes have been tried via open-fieldlines, in which concentric electrodes located in both inner and outer divertors as well as end-on plasma guns are electrically biased independently. As a result of effective outer-divertor electrode biasing alone, FRC plasma diamagnetism duration has reached up to ~9 ms which is equivalent to C-2U plasma duration. Magnetic field flaring/expansion in both inner and outer divertors plays an important role in creating a thermal insulation on open-field-lines to reduce a loss rate of electrons, which leads to improvement of the edge as well as core FRC confinement properties.