The aim of this study was to investigate the impact of the COVID-19 pandemic on the attitudes towards the lifting of con nement. Methods: The data were collected using a questionnaire applied to 344 people in different regions of Algeria from April 21, 2020, for two weeks afterward, in order to determine the attitudes of the Algerian people towards the post-coronavirus COVID-19 phase. Results: The results of this study indicate that 94.2% of respondents insist on lifting the con nement to apply gradually and partially. Accordingly, there is a signi cant impact of gender and age on social attitudes towards the post-coronavirus phase. Similarly, the results highlighted the existence of a positive level of attitude towards the post-coronavirus phase COVID-19 in the need to digitize education, digitize social transactions, and develop sustainable transport and the public health sector. Results: People living in con nement indicate that it is necessary to prepare for the post-coronavirus period, in particular through the vital sectors linked to daily life.

National Institutes of Health Intramural funds and St Baldrick's Foundation.

Coronaviruses (CoVs) have formerly been regarded as relatively harmless respiratory pathogens to humans. However, two outbreaks of severe respiratory tract infection, caused by the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV), as a result of zoonotic CoVs crossing the species barrier, caused high pathogenicity and mortality rates in human populations. This brought CoVs global attention and highlighted the importance of controlling infectious pathogens at international borders. In this review, we focus on our current understanding of the epidemiology, pathogenesis, prevention, and treatment of SARS-CoV and MERS-CoV, as well as provides details on the pivotal structure and function of the spike proteins (S proteins) on the surface of each of these viruses. For building up more suitable animal models, we compare the current animal models recapitulating pathogenesis and summarize the potential role of host receptors contributing to diverse host affinity in various species. We outline the research still needed to fully elucidate the pathogenic mechanism of these viruses, to construct reproducible animal models, and ultimately develop countermeasures to conquer not only SARS-CoV and MERS-CoV, but also these emerging coronaviral diseases.