Highlights d DLBCLs expressing LMO2 protein have deficient homologous recombination DNA repair d LMO2 interacts with and requires 53BP1 to inhibit homologous recombination d LMO2 expression sensitizes tumor cells to PARP1/2 inhibitors (PARPi) d PARPi and chemotherapy synergistically inhibit the growth of LMO2-positive tumors
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