Monte Carlo simulation is an essential tool in emission tomography that can assist in the design of new medical imaging devices, the optimization of acquisition protocols and the development or assessment of image reconstruction algorithms and correction techniques. GATE, the Geant4 Application for Tomographic Emission, encapsulates the Geant4 libraries to achieve a modular, versatile, scripted simulation toolkit adapted to the field of nuclear medicine. In particular, GATE allows the description of time-dependent phenomena such as source or detector movement, and source decay kinetics. This feature makes it possible to simulate time curves under realistic acquisition conditions and to test dynamic reconstruction algorithms. This paper gives a detailed description of the design and development of GATE by the OpenGATE collaboration, whose continuing objective is to improve, document and validate GATE by simulating commercially available imaging systems for PET and SPECT. Large effort is also invested in the ability and the flexibility to model novel detection systems or systems still under design. A public release of GATE licensed under the GNU Lesser General Public License can be downloaded at http:/www-lphe.epfl.ch/GATE/. Two benchmarks developed for PET and SPECT to test the installation of GATE and to serve as a tutorial for the users are presented. Extensive validation of the GATE simulation platform has been started, comparing simulations and measurements on commercially available acquisition systems. References to those results are listed. The future prospects towards the gridification of GATE and its extension to other domains such as dosimetry are also discussed.

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The impinging position of a 511 keV photon onto a continuous scintillator can be obtained from the light distribution measured by a pixelated photodetector such as avalanche photodiode (APD) arrays. This information is extracted using neural networks trained for events with a particular incidence angle. Using a 20 10 10 mm block of lutetium oxyorthosilicate mounted onto a S8550 Hamamatsu APD matrix we achieved an intrinsic resolution of 1.9 mm full-width at half-maximum (FWHM) for perpendicular incident photons and 2.6 mm FWHM at a 40 incidence angle. A possible implementation for tomographic imaging is presented. Index Terms-Depth of interaction (DOI), neural network (NN), positron emission tomorgraphy (PET).