No abstract

Microtubule disassembly inhibitory properties have been established for the known polyisoprenylated benzophenones xanthochymol (1a) and guttiferone E (1b). The compounds were isolated from the fruits of Garcinia pyrifera collected in Malaysia. A structure-activity relationship study, including natural and semisynthetic derivatives, delineated some structural features necessary for the interaction with tubulin within this compound class.

Three new stilbene derivatives, quadrangularins A, B, and C (2−4), have been isolated from the stems of Cissus quadrangularis, together with four known ones:  resveratrol, piceatannol, pallidol (1), and parthenocissine A (5). Structure elucidation of the new compounds was achieved using 2D NMR experiments.