24 95 (10; A) 204-206 (PrOH) 46" (5; B) 91 (41; C) 33'(6; B) 60d (42; C) e (8; B) 83 (15; B) 97 (44; C) 95 (16; B) 73 (45; C) h (40; C) 12 (45; C) 25 96(11; A) 158-160b (PrOH) 26 98 (13; A) 96-98 (hexane-C,H,) 27 97 (17; A) 21 2-214 (acetone) 28 98 (18; A) 198-200 (acetone) 34 181 (I; B) 1 79-1 8 1 (toluene) 46 i (16; B) 185-187 (Pr'OH) ~~~ ~ ~ Macrocyclic derivative 36 (23% yield) was also formed. M.p. 157-1 59 "C (ref. 13). ' Macrocyclic derivative 37 (40% yield) was also formed. 9, 748.

The intramolecular cyclization of N,N‐disubstituted 2′‐halogenophenacylamine hydrobromides 1a–h to 1,1‐disubstituted 3‐oxoindolinium bromides 3a–f has been studied. Some 3‐oxoindolinium salts have also been prepared according to a different pattern by intramolecular cyclization of the phenacyl halides resulting from the bromination of 2′‐(dialkylamino)acetophenones 4 or from the treatment of 2′‐(dialkylamino)‐2‐diazoacetophenones 6a, b with hydrogen halides. Removal of hydrogen halide in salts 3a–g gives indolylio oxides 2a–g; these compounds have been shown to be unstable and decompose easily giving in general complex mixtures; only in the case of tetrahydroisoquinoline‐derived ylides 2e, g we have observed clear‐cut reactions leading, via a Stevens rearrangement followed by oxidation, to the 6,7‐dihydro‐13H‐indolo[2,1‐b][3]benzazepin‐13‐ones 8a, b.

Two different neural network models able to predict both oral absorption (OA) and blood‐brain barrier (BBB) permeability of structurally diverse drugs in use clinically are presented here. Using the descriptors generated by CODES, a program which codifies molecules from a topological point of view, we avoid the uncertain choice of molecular conformation and physicochemical parameters. In this work, a method called Reduction of Dimensions, designed for compressing data, is applied for the first time in order to minimize the bias factor added to a QSAR study when the selection of descriptors are performed.

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