This document is an update to the 2011 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2C9 and VKORC1 genotypes and warfarin dosing. Evidence from the published literature is presented for CYP2C9, VKORC1, CYP4F2, and rs12777823 genotype-guided warfarin dosing to achieve a target international normalized ratio of 2-3 when clinical genotype results are available. In addition, this updated guideline incorporates recommendations for adult and pediatric patients that are specific to continental ancestry.

We report a theoretical-experimental investigation of electron scattering by dichloromethane (CH 2 Cl 2) in the low-and intermediate energy ranges. Experimental elastic differential cross sections (DCS), in the incident electron energy range of 0.5-800eV and scattering angle range of 10°-130°, were measured using a crossed beam relative flow technique. Integral and momentumtransfer cross sections were determined from the experimental DCS. Theoretical elastic differential, integral, and momentum-transfer, as well as grand-total, and total absorption cross sections were also calculated for impact energies ranging from 0.5 to 500eV. A complex optical Hartree-Fock potential represented the electron-target interaction and a single-center expansion method combined with a Padé approximation was used to solve the scattering equations. Three resonances: a 2 A 1 C-Cl kσ * resonance centered at about 3.5eV, a 2 B 2 C-Cl kσ * resonance centered at about 5eV and a broad 2 A 1 C-H kσ * resonance at about 10eV were detected in our calculation. Further calculations of DCS were performed at an intermediate energy range of 50-800eV, using the independent-atom model in which the atomic complex optical potential and partial-wave method were used to obtain atomic scattering amplitudes. Comparisons of our experimental and theoretical data with very recent experimental and theoretical results are made.