The expression of mesothelin correlates with a poor prognosis in patients with breast cancer. Since mesothelin plays a role in cancer metastasis in association with CA125, we herein examined the expression of mesothelin and CA125, and the clinicopathological meaning and prognosis of the co-expression of mesothelin and CA125 in breast cancer. Our results showed that among 478 patients, mesothelin and CA125 were co-expressed in 48 (10 %), mesothelin only in 75 (16 %), CA125 only in 217 (45 %), and neither in 234 (49 %). A high correlation was observed between the expression of mesothelin and CA125 (P =0.0004). The co-expression of mesothelin and CA125 correlated with poor patient relapse-free survival (RFS) (P = 0.0001) and was identified as an independent predictor of RFS by Cox’s multivariate analysis. In conclusion, this is the first to report the prognostic significance of the co-expression of mesothelin and CA125 in breast cancer. The co-expression of mesothelin and CA125 may be clinically useful for prognostication after surgical therapy in patients with breast cancer.

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We report the case of a girl with a 46 , XY karyotype containing the sex determining region Y gene (SRY). She was 14 years old, with the height of 131 .2 cm (-4.5 SD). She had a low hair line, shield-shaped chest and multiple pigmented naevi on her face. The external genitalia were normal female. No inguinal or labial masses were found. Chromosomal analysis from blood lymphocytes and skin fibroblasts revealed a 46, XY karyotype. The basal levels of serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) and their responses to LH-releasing hormone (RH) stimulation were elevated; the insulin-like growth factor-I (IGF-I), thyroid function and growth hormone (GH) secretory responses to insulin and glucagon were normal. SRY was identified on the short arm of the Y chromosome using Y-specific deoxyribonucleic acid (DNA) probes.There were no mutations in the SRY by direct sequencing analysis. Pelvic ultrasound and magnetic resonance imaging (MRI) did not reveal internal genitalia. Gonadectomy may be necessary because she has a substantial risk of developing malignant germ cell neoplasia. Two questions arise: 1) why was male sexual differentiation inhibited although she had a normal SRY, and 2) why did she have the appearance of Turner syndrome?