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Introduction. The current evidence indicates that the severity of the coronavirus disease 2019 (COVID-19) is lower in the pediatric population but local data are still limited. Objective: To characterize the clinical and epidemiological aspects of COVID-19 infection in patients younger than 18 years in Argentina. Population and methods. Cross-sectional, observational, and analytical study of confirmed COVID-19 patients aged 0-18 years seen between March 2020 and March 2021 at 19 referral children's hospitals of Argentina. A multivariate analysis was done to identify predictors of severe cases. Results. A total of 2690 COVID-19 cases were included: 77.7% lived in the Metropolitan Area of Buenos Aires; 50.1% were males; patients' median age was 5.6 years. Of them, 90% were seen during epidemiological weeks 20-47 of 2020; 60.4% had a history of contact with COVID-19 patients; and 96.6% in their family setting. Also, 51.4% had respiratory symptoms; 61.6%, general symptoms; 18.8%, gastrointestinal symptoms; 17.1%, neurological symptoms; 7.2%, other symptoms; and 21.5% were asymptomatic. In addition, 59.4% of patients were hospitalized and 7.4% had a severe or critical course. A total of 57 patients developed multisystem inflammatory syndrome. A history of asthma, bronchopulmonary dysplasia, congenital heart disease, moderate to severe malnutrition, obesity, chronic neurological disease and/or age younger than 6 months were independent predictors of severity. Living in a vulnerable neighborhood was a protective factor. Conclusions. More than half of cases referred a history of contact with COVID-19 patients in the family setting. Hospitalization was not based on clinical criteria of severity. Severity was associated with the presence of certain comorbidities.

BackgroundVaricella (VZV) is one of the most frequent exanthematic diseases in childhood. In Argentina, around 150,000–180,000 total cases per year are registered; however, underreport exists and some 400,000 cases are estimated to occur annually. Varicella vaccine (VV) was included in the national immunization schedule (NIS) in 2015, with a 1-dose schedule administered at 15 months of age. The information provided by epidemiological surveillance is essential to evaluate the impact of public health decisions. Our objective was to describe and to compare the epidemiological situation of VZV infections in Argentina in two periods: pre (2010–2014) and post (2016–2017) vaccine introduction in NIS.MethodsDescriptive study. We compared cases and incidence rates (R) of VZV per 100,000 population (global and disaggregated by age) reported to the National Health Surveillance System; in pre (Pre-VV) and post-vaccination (Post-VV) periods. Data analysis of 2015 was excluded since it was considered a transition year.ResultsVaccination coverage for 2015 was 44.7%; 74.4% in 2016 and 75.5% in 2017. 728,392 cases of VZV were notified (R = 362,1) in Pre-VV period and 176,995 cases in Post-VV (R = 220.6), with a global incidence rate reduction of 39% (IC 95% =38.9–39.6; P < 0.001). Both 12–24 months of age and 2–4 years old groups (Pre-VV R 2,253 and Post-VV R 1,077; Pre-VV R 2,400 and Post-VV R 1,165, respectively) showed the greatest reductions in incidence rates (–52.2% [IC 95% 51.3–53] P <0.001 and –51.4% [IC 95% 51–52] P <0.001). Besides, age groups not affected by vaccination (<1 year, 5–9 years, and 10–14 years) presented minor but significant reductions (–49.1% [95% CI 44.5–53.4] P < 0.001; –23% [IC95% 22.4–23.6] P <0.001, and –17% [IC95% 16.4-19] P <0.001, respectively).ConclusionThree years after the implementation of VZV vaccination strategy, a significant incidence rates reduction is recorded, especially in children <5 years old, despite suboptimal coverage. Improving vaccination coverage will likely reflect a greater impact on the burden of disease.Disclosures All authors: No reported disclosures.

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