Aims: Patients with cirrhosis and clinically significant portal hypertension (CSPH) usually have concomitant secondary hypersplenism, and splenectomy (Spx) is an option for treating these patients in the Asia-Pacific region. CSPH is the most important risk factor for postoperative liver dysfunction (PLD) in patients with hepatocellular carcinoma (HCC) and cirrhosis undergoing liver resection. However, the impact of simultaneous Spx and hepatectomy in patients with HCC and CSPH remains unclear. In this study, we aimed to determine the impact of simultaneous Spx on the posthepatectomy outcomes in these patients. Methods: This study included 691 consecutive patients with hepatitis B virusrelated HCC, cirrhosis, and CSPH. These included 565 patients who underwent hepatectomy only (non-Spx group) and 126 who underwent simultaneous hepatectomy and splenectomy (Spx group). We analyzed the effect of 25 preoperative and 5 intraoperative factors on postoperative outcomes using logistic regression. To overcome any possible selection bias, confounders were balanced by propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) analyses, and subgroup analyses were performed within the PSM-matched groups. Results: Logistic regression analyses revealed that Spx was an independent protective factor for severe postoperative liver dysfunction (SPLD; odds ratio [OR] = 0.22, 95% confidence interval [CI]: 0.11-0.43, p < 0.001) and 90-day SPLD-related mortality (OR = 0.21, 95% CI: 0.06-0.55, p = 0.004), respectively. Spx was also independently associated with a higher overall survival rate (hazard ratio = 0.63, 95% CI = 0.47-0.85, p = 0.002) based on Cox regression analysis. PSM and IPTW models showed that the benefit of Spx was also consistent across the major and minor hepatectomy subgroups examined. Conclusion: Simultaneous Spx improved the outcomes of patients with HCC, cirrhosis, and CSPH treated with hepatectomy, including patients who underwent major and minor hepatectomies.
People often need to plan how to allocate their attention across different tasks. In this paper, we run two experiments to study a stylized version of this attention-allocation problem between strategic tasks. More specifically, we present subjects with pairs of 2 × 2 games, and for each pair, we give them 10 seconds to decide how they would split a fixed time budget between the two games. Then, subjects play both games without time constraints, and we use eye-tracking to estimate the fraction of time they spend on each game. We find that subjects’ planned and actual attention allocation differ and identify the determinants of this mismatch. Further, we argue that misallocations can be relevant in games in which a player’s strategy choice is sensitive to the time taken to reach a decision. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Funding: Work on this project was provided by the National Science Foundation [Grant SES 1724550] “Collaborative Research: Attention in Games and Decisions,” awarded to A. Schotter and E. R. Schotter. The work of M. Ribeiro and M. Zou was supported by the Center for Experimental Economics Social Science at New York University. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2023.4834 .
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