Human skin diseases have become increasingly prevalent in recent decades, with millions of individuals in developed countries experiencing monkeypox. Such conditions often carry less obvious but no less devastating risks, including increased vulnerability to monkeypox, cancer, and low self-esteem. Due to the low visual resolution of monkeypox disease images, medical specialists with high-level tools are typically required for a proper diagnosis. The manual diagnosis of monkeypox disease is subjective, time-consuming, and labor-intensive. Therefore, it is necessary to create a computer-aided approach for the automated diagnosis of monkeypox disease. Most research articles on monkeypox disease relied on convolutional neural networks (CNNs) and using classical loss functions, allowing them to pick up discriminative elements in monkeypox images. To enhance this, a novel framework using Al-Biruni Earth radius (BER) optimization-based stochastic fractal search (BERSFS) is proposed to fine-tune the deep CNN layers for classifying monkeypox disease from images. As a first step in the proposed approach, we use deep CNN-based models to learn the embedding of input images in Euclidean space. In the second step, we use an optimized classification model based on the triplet loss function to calculate the distance between pairs of images in Euclidean space and learn features that may be used to distinguish between different cases, including monkeypox cases. The proposed approach uses images of human skin diseases obtained from an African hospital. The experimental results of the study demonstrate the proposed framework’s efficacy, as it outperforms numerous examples of prior research on skin disease problems. On the other hand, statistical experiments with Wilcoxon and analysis of variance (ANOVA) tests are conducted to evaluate the proposed approach in terms of effectiveness and stability. The recorded results confirm the superiority of the proposed method when compared with other optimization algorithms and machine learning models.

Breast cancer (BC) is a type of tumor that develops in the breast cells and is one of the most common cancers in women. Women are also at risk from BC, the second most life-threatening disease after lung cancer. The early diagnosis and classification of BC are very important. Furthermore, manual detection is time-consuming, laborious work, and, possibility of pathologist errors, and incorrect classification. To address the above highlighted issues, this paper presents a hybrid deep learning (CNN-GRU) model for the automatic detection of BC-IDC (+,−) using whole slide images (WSIs) of the well-known PCam Kaggle dataset. In this research, the proposed model used different layers of architectures of CNNs and GRU to detect breast IDC (+,−) cancer. The validation tests for quantitative results were carried out using each performance measure (accuracy (Acc), precision (Prec), sensitivity (Sens), specificity (Spec), AUC and F1-Score. The proposed model shows the best performance measures (accuracy 86.21%, precision 85.50%, sensitivity 85.60%, specificity 84.71%, F1-score 88%, while AUC 0.89 which overcomes the pathologist’s error and miss classification problem. Additionally, the efficiency of the proposed hybrid model was tested and compared with CNN-BiLSTM, CNN-LSTM, and current machine learning and deep learning (ML/DL) models, which indicated that the proposed hybrid model is more robust than recent ML/DL approaches.

Two-dimensional mixed convection radiative nanofluid flow along with the non-Darcy permeable medium across a wavy inclined surface are observed in the present analysis. The transformation of the plane surface from the wavy irregular surface is executed via coordinate alteration. The fluid flow has been evaluated under the outcomes of heat source, thermal radiation, and chemical reaction rate. The nonlinear system of partial differential equations is simplified into a class of dimensionless set of ordinary differential equations (ODEs) through a similarity framework, where the obtained set of ODEs are further determined by employing the computational technique parametric continuation method (PCM) via MATLAB software. The comparative assessment of the current outcomes with the earlier existing literature studies confirmed that the present findings are quite reliable, and the PCM technique is satisfactory. The effect of appropriate dimensionless flow constraints is studied versus energy, mass, and velocity profiles and listed in the form of tables and figures. It is perceived that the inclination angle and wavy surface assist to improve the flow velocity by lowering the concentration and temperature. The velocity profile enhances with the variation of the inclination angle of the wavy surface, non-Darcian term, and wavy surface term. Furthermore, the rising value of Brownian motion and thermophoresis effect diminishes the heat-transfer rate.