Brain Function of TAAR5 Thus, anxiolytic and/or antidepressant action of future TAAR5 antagonists could be predicted. In general, "olfactory" TAAR-mediated brain circuitry may represent a previously unappreciated neurotransmitter system involved in the transmission of innate odors into emotional behavioral responses.

Neuromuscular interfaces are required to translate bioelectronic technologies for application in clinical medicine. Here, by leveraging the robotically controlled ink-jet deposition of low-viscosity conductive inks, extrusion of insulating silicone pastes, and in situ activation of electrode surfaces via cold-air plasma, we show that soft biocompatible materials can be rapidly printed for the on-demand prototyping of customized electrode arrays well-adjusted to specific anatomical environments, functions and experimental models. We also show that the printed bioelectronic interfaces allow for long-term integration and functional stability, for the monitoring and activation of neuronal pathways in the brain, spinal cord and neuromuscular system of cats, rats and zebrafish. The technology might enable personalized bioelectronics for neuroprosthetic applications. One-sentence editorial summary:Customized soft electrode arrays well-adjusted to specific anatomical environments, functions and experimental models can be rapidly prototyped via the robotically controlled deposition of conductive inks and insulating inks.

No abstract