Changes in endocardial pressure (EP) have important clinical significance for heart failure patients with impaired cardiac function. As a vital parameter for evaluating cardiac function, EP is commonly monitored by invasive and expensive cardiac catheterization, which is not feasible for long-term and continuous data collection. In this work, a miniaturized, flexible, and selfpowered endocardial pressure sensor (SEPS) based on triboelectric nanogenerator (TENG), which is integrated with a surgical catheter for minimally invasive implantation, is reported. In a porcine model, SEPS is implanted into the left ventricle and the left atrium. The SEPS has a good response both in low-and high-pressure environments. The SEPS achieves the ultrasensitivity, real-time monitoring, and mechanical stability in vivo. An excellent linearity (R 2 = 0.997) with a sensitivity of 1.195 mV mmHg −1 is obtained. Furthermore, cardiac arrhythmias such as ventricular fibrillation and ventricular premature contraction can also be detected by SEPS. The device may promote the development of miniature implantable medical sensors for monitoring and diagnosis of cardiovascular diseases.
High-density polycycloalkanes were first produced with cellulose by a highly integrated route that features a selective hydrogenolysis of cellulose to 2,5hexanedione under mild conditions, followed by the direct synthesis of polycycloalkanes with 2,5-hexanedione and hydrogen over a dual-bed catalyst system. The polycycloalkane mixture as obtained has a high density (0.88 g mL À1 ) and low freezing point (225 K). In real application, they can be used as advanced aviation fuel or additives to improve the volumetric heat values of conventional aviation fuels.
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