The effect of the non-steroidal anti-inflammatory drug ketoprofen on the post farrowing phase of sows was studied in a randomized, blinded, placebo-controlled trial. Ketoprofen (3mg/kg) was administered intramuscularly to 20 healthy sows for 3 days post-partum (p.p.). The control group (n=20) received a saline placebo. Backfat, number of days of constipation and days before feed refusal were measured. Body condition (BCS) and shoulder sores were scored for 1 week p.p. Changes in BCS, backfat and shoulder sore scores were analysed with ANOVA. Blood was collected on days -1, 0, 5 and 14 with respect to medication. Aspartate aminotransferase (AST), creatinine kinase (CK), haptoglobin and serum amyloid A (SAA) were quantified and analysed with a Mann-Whitney U test. BCS and backfat decreased less following ketoprofen administration than with the placebo (-0.08 ± 0.2 vs. -0.8 ± 0.2, 1.0 ± 0.8mm vs. -2.0 ± 0.9 mm, respectively; P<0.05 for both) during the first 2 weeks of lactation. The shoulder sore score deterioration was milder during days 4-6 p.p. with ketoprofen than placebo (P<0.05). Duration of constipation was shorter with ketoprofen than placebo (5.5 ± 0.3 vs. 6.4 ± 0.3 days p.p.; P<0.05). Incidences of feed refusal occurred later in the ketoprofen group than in the placebos (9.6 ± 0.9 vs. 3.8 ± 0.8 days p.p.; P<0.05). AST and SAA values were higher after ketoprofen administration than placebo on day 5 p.p. (P<0.05). It was concluded that ketoprofen appeared to benefit sows during the first 2 weeks post farrowing, but caused some tissue irritation.
From 1.1.2013 EU legislation will permit stall-housing of dry sows for only 4 weeks post-service. Stalls are associated with compromised animal welfare, but group housing comes with risks from social confrontations. Studies on housing effects on fertility have produced contradictory results as systems are inconsistently defined. Effects of housing on pregnancy rate 28 days post-service (P28), early disruption of pregnancy (EDP) and behaviour were investigated in 12 replicates of 40 sows. Half of the animals were stalled (treatment S, mean parity 2.4) and half group-housed adjacent on 5.1 m(2) deep litter per sow (treatment G, mean parity 2.3). Pregnancy was detected using real-time ultrasound. An EDP-diagnosis required a drop of salivary progesterone concentration from >15.9 to <15.9 mmol/l in a series of samples taken on days 17, 20, 24 and 27 post-service. Behaviour was scan sampled on day 27 for 120 min with 10-min intervals. Data was analysed using mixed regression models in MLwiN. Treatment S increased the odds for P28 with 2.3 and the pregnancy rate of a treatment group with 0.1 compared with G. G increased the odds for EDP with 4.6. Treatment did not affect total exploratory or total passive behaviour. S sows explored floor and fixtures (not bedding) more and performed more passive sitting than G sows. Social stress may have caused the impaired reproductive performance in G sows. S sows showed behavioural signs of decreased welfare, but no corresponding reproductive effects. An interdisciplinary approach is needed when evaluating the appropriateness of housing systems.
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