Since the mid 1970s, cancer has been described as a process of Darwinian evolution, with somatic cellular selection and evolution being the fundamental processes leading to malignancy and its many manifestations (neoangiogenesis, evasion of the immune system, metastasis, and resistance to therapies). Historically, little attention has been placed on applications of evolutionary biology to understanding and controlling neoplastic progression and to prevent therapeutic failures. This is now beginning to change, and there is a growing international interest in the interface between cancer and evolutionary biology. The objective of this introduction is first to describe the basic ideas and concepts linking evolutionary biology to cancer. We then present four major fronts where the evolutionary perspective is most developed, namely laboratory and clinical models, mathematical models, databases, and techniques and assays. Finally, we discuss several of the most promising challenges and future prospects in this interdisciplinary research direction in the war against cancer.

The way doctors deliver bad news has a significant impact on the therapeutic process. In order to facilitate doctor's training, we have developed an embodied conversational agent simulating a patient to train doctors to break bad news. In this article, we present an evaluation of the virtual reality training platform comparing the users' experience depending on the virtual environment displays: a PC desktop, a virtual reality headset, and four wall fully immersive systems. The results of the experience, including both real doctors and naive participants, reveal a significant impact of the environment display on the perception of the user (sense of presence, sense of co-presence, perception of the believability of the virtual patient), showing, moreover, the different perceptions of the participants depending on their level of expertise.