The This report also includes a summary of global cancer mortality rates using data from the World Health Organization. (CA Cancer J Clin 2000;50:7-33.) IntroductionCancer is an important public health concern in the United States and around the world. To provide an up-to-date perspective on the occurrence of cancer, the American Cancer Society presents an overview of cancer frequency, incidence, mortality, and survival statistics for the year 2000. Methods ESTIMATED NEW CANCER CASESBecause the US does not have a nationwide cancer registry, the exact number of new cases of cancer diagnosed each year in the US and in individual states is not known. Consequently, we first estimated the number of new cancer cases occurring annually in the US from 1979 through 1996 using population data reported by the US Bureau of the Census and age-specific cancer incidence rates collected by the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program. 1 We fitted these annual cancer case estimates to an autoregressive quadratic model to forecast the number of cancer cases expected to be diagnosed in the US in the year 2000 (Table 1, Fig. 1). 2Between 1987 and 1992, the incidence rate of prostate cancer increased 85%, followed by a decline of 29% between 1992 and 1996. 3 The sharp increase in incidence followed by the decline in recent years probably reflects extensive use of prostate-specific antigen (PSA) screening in a previously unscreened population and the subsequent increase in diagnoses at an early stage. 4 We assumed that the number of prostate cancer cases would approximate the rates observed prior to widespread use of PSA screening, and there-

The Surveillance Research Program of the American Cancer Society's Department of Epidemiology and Surveillance Research reports its 33rd annual compilation of cancer frequency, incidence, mortality, and survival data for the United States.

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We present incidence, mortality, and survival statistics to provide a perspective on the patterns of cancer occurrence in the United States population. Estimates of the numbers of new cancer cases and deaths for 1996 are presented according to sex, site, and state. We also present information on cancer and noncancer mortality, the probability of developing cancer at certain ages, and cancer survival in adults and children. IncidenceBecause no nationwide cancer registry exists, there is no way of knowing exactly how many new cases of cancer are diagnosed annually in the United States. We