The neurocognitive basis of the effect of long-term high altitude exposure on voluntary attention is unclear. Using event related potentials, the high altitude group (people born in low altitude but who had lived at high altitude for 3 years) and the low altitude group (living in low altitude only) were investigated using a voluntary spatial attention discrimination task under high and low perceptual load conditions. The high altitude group responded slower than the low altitude group, while bilateral N1 activity was found only in the high altitude group. The P3 amplitude was smaller in the high altitude compared to the low altitude group only under high perceptual load. These results suggest that long-term exposure to high altitudes causes hemispheric compensation during discrimination processes at early processing stages and reduces attentional resources at late processing stages. In addition, the effect of altitude during the late stage is affected by perceptual load. More than 140 million people live permanently at high altitudes (.2,500 m above sea level) in North, Central, and South America, East Africa, and Asia 1 . As of 2006, approximately 12 million people live permanently on the Qinghai-Tibetan Plateau, and 71.14% of them live between 2,500 to 4,500 m. In addition, hundreds of thousands of people travel from lowland China to the Tibetan plateau every year; about 6 million Han lowland immigrants now live there permanently 2,3 . The largest and most important impact of living in a high altitude is hypoxia, which is caused by a reduction of oxygen in the air, and affects cognition. Sustained exposure to high altitude leads to cognitive decrement, such as impairment in attention, memory, judgment, and emotion 4 . Research has demonstrated that cognitive impairment due to altitude starts at 2,500 m above sea level [5][6][7] , because brain vulnerability to hypoxia increases beginning at 2,500 m 8 . Spatial attention may be particularly affected by high altitude exposure. First, the attentional impairment caused by exposure to high altitudes has been found in behavioral tests of visual attention (e.g., the digit symbol substitution test and visual search task) 9,10 , with slowed reaction times at higher altitudes. Second, previous studies have provided neuroimaging and electrophysiological evidence of the impact of high altitude exposure on the human brain [11][12][13] . In the neuroimaging study, brain areas related to attention processing-including the occipital lobe, parietal lobe, sensory-perceptual regions and frontoparietal attentional networks-were found to be affected by high altitude exposure 13,14 . In the electrophysiological study, the parietal distributed P3, which is crucially involved in maintaining attention, was the event-related potential (ERP) component most significantly affected by hypoxia 11,15 . Specifically, smaller and later P3 component responses have been reported for participants at high altitude than in those at the low altitudes, suggesting that cognitive abilities are sensitiv...

To investigate the effects of high-altitude exposure on response inhibition, event-related potential (ERP) components N2 and P3 were measured in Go/NoGo task. The participants included an ‘immigrant’ high-altitude group (who had lived at high altitude for three years but born at low altitude) and a low-altitude group (living in low altitude only). Although the behavioural data showed no significant differences between the two groups, a delayed latency of NoGo-N2 was found in the high-altitude group compared to the low-altitude group. Moreover, larger N2 and smaller P3 amplitudes were found in the high-altitude group compared to the low-altitude group, for both the Go and NoGo conditions. These findings suggest that high-altitude exposure affects response inhibition with regard to processing speed during the conflict monitoring stage. In addition, high altitude generally increases the neural activity in the matching step of information processing and attentional resources. These results may provide some insights into the neurocognitive basis of the effects on high-altitude exposure on response inhibition.

The neurocognitive basis of the effect of long-term high altitude exposure on conflict control is unclear. Event related potentials (ERPs) were recorded in a flanker task to investigate the influence of high altitude on conflict control in the high-altitude group (who had lived at high altitude for three years but were born at low altitude) and the low-altitude group (living in low altitude only). Although altitude effect was not significant at the behavioral level, ERPs showed cognitive conflict modulation. The interaction between group and trial type was significant: P3 amplitude was greater in the low-altitude group than in the high-altitude group in the incongruent trial. This result suggests that long-term exposure to high altitude affects conflict control in the conflict-resolving stage, and that attentional resources are decreased to resist the conflict control in the high-altitude group.

The student’s attitude towards the doctor-nurse integrated teaching model and Maslow’s hierarchy of needs theory is an important topic in clinical teaching. In this study, choosing 134 intern doctors and practice nurses who intern from January to December 2020. 67 students are selected as the control group, and the traditional interns teaching mode is adopted. 67 students are selected as the experimental group and Maslow’s hierarchy of needs theory to apply in the doctor-nurse integrated teaching mode. The results show that the doctor-nurse integrated teaching model are accepted by most students, and the application of Maslow’s hierarchy of needs theory in the clinical interns has advantages over the traditional model.