No abstract

The pan-cancer analysis of whole genomes The expansion of whole-genome sequencing studies from individual ICGC and TCGA working groups presented the opportunity to undertake a meta-analysis of genomic features across tumour types. To achieve this, the PCAWG Consortium was established. A Technical Working Group implemented the informatics analyses by aggregating the raw sequencing data from different working groups that studied individual tumour types, aligning the sequences to the human genome and delivering a set of high-quality somatic mutation calls for downstream analysis (Extended Data Fig. 1). Given the recent meta-analysis

Highlights d PDAC regional heterogeneity stems from sub-tumor microenvironments (subTMEs) d SubTMEs exhibit distinct immune phenotypes and CAF differentiation states d SubTMEs execute distinct tumor-promoting and chemoprotective functions d Intratumoral subTME co-occurrence links stromal heterogeneity to patient outcome