SUMMARYBackground: Failures of Helicobacter pylori eradication in children are common. Aim: To evaluate the efficacy of amoxicillin, bismuth subcitrate and omeprazole and nifuratel or furazolidone for H. pylori eradication in children who failed initial treatment with a standard triple therapy. Methods: Seventy-six consecutive H. pylori-positive paediatric out-patients (aged 12-16 years; mean age 13.7 ± 1.4) with chronic abdominal complaints who had failed one attempt of eradication of H. pylori using metronidazole-containing triple therapy were enrolled.It was an open prospective study. Patients were randomized to receive a 2-week course of bismuth subcitrate (8 mg/kg/day, q.d.s.), amoxicillin (50 mg/ kg/day, q.d.s.), with either nifuratel (15 mg/kg/day,

The role of immunohistochemistry in the solution of a series of clinial oncology problems is studied on the basis of 300 observations taking into account current demands of histogenetic diagnosis of tumors. The most rational schemes of immunohistochemical diagnosis based on the use of minimum set of antibodies at the first and second stages of the study are given. The importance of the use of immunohistochemistry in differential histogenetic diagnosis of the most widely met tumors of a person is emphasized. This method significantly extends the possibilities of morphological verification of tumors. The prospects of the development of histochemistry for oncologic clinics are considered.

Findings suggest that the present treatment regimen is effective enough in the resolution of H. pylori-associated peptic ulcer disease of childhood.