Purpose To develop a new high‐dimensionality undersampled patch‐based reconstruction (HD‐PROST) for highly accelerated 2D and 3D multi‐contrast MRI. Methods HD‐PROST jointly reconstructs multi‐contrast MR images by exploiting the highly redundant information, on a local and non‐local scale, and the strong correlation shared between the multiple contrast images. This is achieved by enforcing multi‐dimensional low‐rank in the undersampled images. 2D magnetic resonance fingerprinting (MRF) phantom and in vivo brain acquisitions were performed to evaluate the performance of HD‐PROST for highly accelerated simultaneous T 1 and T 2 mapping. Additional in vivo experiments for reconstructing multiple undersampled 3D magnetization transfer (MT)‐weighted images were conducted to illustrate the impact of HD‐PROST for high‐resolution multi‐contrast 3D imaging. Results In the 2D MRF phantom study, HD‐PROST provided accurate and precise estimation of the T 1 and T 2 values in comparison to gold standard spin echo acquisitions. HD‐PROST achieved good quality maps for the in vivo 2D MRF experiments in comparison to conventional low‐rank inversion reconstruction. T 1 and T 2 values of white matter and gray matter were in good agreement with those reported in the literature for MRF acquisitions with reduced number of time point images (500 time point images, ~2.5 s scan time). For in vivo MT‐weighted 3D acquisitions (6 different contrasts), HD‐PROST achieved similar image quality than the fully sampled reference image for an undersampling factor of 6.5‐fold. Conclusion HD‐PROST enables multi‐contrast 2D and 3D MR images in a short acquisition time without compromising image quality. Ultimately, this technique may increase the potential of conventional parameter mapping.

The proposed approach enables free-breathing whole-heart 3D CMRA with isotropic sub-millimeter resolution in <5 min and achieves improved coronary artery visualization in a short and predictable scan time.