PBM therapy has no deleterious effects on ddMSCs. Although no other clear conclusion was obtained because of the scarce number of publications, the results of these studies are pointing to an important tendency of PBM therapy to improve ddMSCs' viability and proliferation.

BackgroundThe regeneration of integrity and tissue homeostasis after injury is a fundamental property and involves complex biological processes fully dynamic and interconnected. Although there are medications prescribed to accelerate the process of wound healing by reducing the exaggerated inflammatory response, comes the need to search for different compounds of Amazonian biodiversity that can contribute to the acceleration of the healing process. Among these products, the copaiba oil-resin is one of the most prominent feature in this scenario, as they have been reported its medicinal properties.MethodsAiming to evaluate the anti-inflammatory and healing effect of copaiba oil-resin (Copaifera reticulata Ducke) in transfixing injury of rats’ tongues first proceeded up the copaiba oil-resin oral toxicity test in 5 male mice to stipulate the therapeutic dose which was established at 200 mg/kg/day. Then it was induced transfixing injury in a total of 15 Wistar rats. The animals were randomly divided into three groups based on the treatment: control group, dexamethasone group and copaiba oil-resin group. After 7 days of treatment, histological slides stained with hematoxylin and eosin was prepared. Immunohistochemistry for CD68 (macrophage marker) was performed and analyzed by the cell counter Image J.ResultsThe acute toxicity test showed that the oil-resin copal has low toxicity. Furthermore, copaiba oil-resin therapy modulates the inflammatory response by decreasing the chronic inflammatory infiltrate, edema and specifically the number of macrophages.ConclusionsThe results indicate the potential of the Amazon region and showed up relevant because therapy with this extract modulates the inflammatory process.

Background Non-carious cervical lesions (NCCLs) have shown a significant incidence and prevalence and have been increasingly associated with people’s lifestyles and youths. This cross-sectional study aimed to determine the prevalence of NCCLs in footballers and to address potential risk indicators. Methods Fourty-three male semi-professional footballers with an average of 27 years old completed a questionnaire and were subjected to intraoral examination in terms of cervical tooth wear, morphological characteristics of NCCLs, tooth sensitivity, occlusal/incisal wear, and malocclusion classification. Also, laboratory assays were performed to determine salivary parameters: flow rate, pH, buffer capacity, level of Ca (calcium), Na (sodium), and K (potassium) ions, and level of cortisol. The data obtained from the questionnaire and intraoral examinations were subjected to Chi-square and Poisson regression models while the data obtained from the laboratory assays were analyzed by using analysis of variance ( p <  0.05). Results The prevalence of NCCLs was 39.5%. The participants presented predominantly initial lesions with signs of mechanical stress. The daily training time was found as a significant risk indicator ( p = 0.028). The multivariate analysis showed a significant difference in the variables daily training time ( p = 0.023), lemon water intake while fasting ( p = 0.002), toothpaste type ( p = 0.004), tooth sensitivity ( p = 0.006); previous orthodontic treatment ( p = 0.003), and occlusion type ( p = 0.008). All participants presented normal salivary parameters and levels of cortisol. Conclusion The prevalence of NCCLs among footballers was remarkable. The premolars were the most affected teeth and presented symptoms/signs of initial lesions. The daily training time was a dominant risk indicator of NCCLs development. Footballers presented adequate salivary parameters and cortisol levels.

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the pulp repair process 2-4). This study evaluated the osteogenic differentiation of human dental pulp stem cells in response to substances released by BD compared with those released from MTA and CHC. The fundamental physicochemical characteristics of pulp capping materials that affect cell differentiation were also analyzed. MATERIALS AND METHODS Ethical requirements This study was approved by the local Human Research Ethics Committee under Protocol CAAE no. 79445117.1.0000.0018. Experimental groups and Biomaterials preparation This was an experimental study, conducted exclusively in the laboratory. The physicochemical and biological characteristics of the dental materials proposed for pulp capping were evaluated according to the following experimental groups: Group 1: BD; Group 2: MTA; Group 3: Two-paste CHC. Biomaterials preparation The BD (Septodont, Saint-Maur-des-Fossés Cedex, France) was prepared by mixing five drops of liquid with the powder (pre-measured in a capsule) using an amalgamator. The white MTA (Angelus, Londrina, PR, Brazil) was prepared at the ratio of one part MTA powder to two