Flexible pressure sensors are attracting great interest from researchers and are widely applied in various new electronic equipment because of their distinct characteristics with high flexibility, high sensitivity, and light weight; examples include electronic skin (E-skin) and wearable flexible sensing devices. This review summarizes the research progress of flexible pressure sensors, including three kinds of transduction mechanisms and their respective research developments, and applications in the fields of E-skin and wearable devices. Furthermore, the challenges and development trends of E-skin and wearable flexible sensors are also briefly discussed. Challenges of developing high extensibility, high sensitivity, and flexible multi-function equipment still exist at present. Exploring new sensing mechanisms, seeking new functional materials, and developing novel integration technology of flexible devices will be the key directions in the sensors field in future.

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In the past 10 years, the development of nanogenerators (NG) has enabled different systems to operate without external power supply. NG have the ability to harvest the mechanical energies in different forms. Human body motions and activities can also serve as the energy source to drive NG and enable self-powered healthcare system. In this review, a summary of several major actual applications of NG in the biomedical fields is made including the circulatory system, the neural system, cell modulation, microbe disinfection, and biodegradable electronics. Nevertheless, there are still many challenges for NG to be actually adopted in clinical applications, including the miniaturization, duration, encapsulation, and output performance. It is also very important to further combine the NG development more precisely with the medical principles. In future, NG can serve as highly promising complementary or even alternative power suppliers to traditional batteries for the healthcare electronics.

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Sustainable ultrathin stretchable power sources have emerged with the development of wearable electronics. They obtain energy from living organisms and the environment to drive these wearable electronics. Here, an ultrathin stretchable and triboelectric nanogenerator (TENG) improved by chargeable carbon black (CB)/thermoplastic polyurethane (TPU) composite material (CT-TENG) is proposed for mechanical energy harvesting and physiological signal sensing. The CB/TPU composite can act as both a stretchable electrode and a triboelectric layer due to the coexistence of conductive CB and dielectric TPU. The CT-TENG demonstrates good stretchability (≈646%), ultrathin thickness (≈50 μm), and a lightweight (≈62 mg). The triboelectric electrode material can be improved by postcharging treatment. With the corona charging process, the output performance of the CT-TENG was improved eightfold and reached 41 V. Moreover, the CT-TENG with a self-powered sensing capability can inspect the amplitude and frequency of different physiological movements. Consequently, the CT-TENG is promising in promoting the development of electronic skins, wearable systems of self-powered sensors, human−machine interactions, soft robotics, and artificial intelligence applications.