Purpose To develop a new 17-item Asthenopia Survey Questionnaire(ASQ-17) by Rasch analysis, and to evaluate a score to predict for its clinical application. Methods This cross-sectional study was conducted in the Eye Hospital of Wenzhou Medical University from January 2018 to January 2021. A total of 739 participants were recruited and 680 were involved in the result analysis. Three rounds of Rasch analysis was used to analyze the psychometric characteristics of items and options, and the receiver operating characteristic curve was used to obtain the cut-off value. Results Four phases were involved in the analyses. Phase 1 assessed the original ASQ-19, which has nineteen items and seven options. Phase 1 adjusted the item scoring mode to a four-point Likert response rating scale and combined the 18th and 19th items into a single one item, then ASQ-18 was obtained. Phase 2 analysis resulted in deleting the 11th item, and the ASQ-17 was obtained. Phase 3 and 4 assessed the new ASQ-17. All the evaluation indexes of ASQ-17 were acceptable. Infit and Outfit MnSq values of all items were 0.67 ~ 1.48, the variance explained by the principal component and the unexplained variance explained by the first contrast were 53.90%~59.40% and 1.50 ~ 1.80 in three dimensions. The curve peak of 0,1,2,3 scores in each dimension were separated from each other and in the same order. PSR and PSI values were 2.80 and 0.89, respectively. The functional differences of each item by gender were − 0.23 ~ 0.51logit, by age were − 0.36 ~ 0.62 logit. The mean person location was − 0.80logit. The mean score of dimension A (9.5 ± 4.1 vs 3.5 ± 3.2), B(7.3 ± 3.3 vs 2.5 ± 2.7), C(4.3 ± 2.2 vs 1.4 ± 2.0) and total (21.1 ± 8.1 vs 7.4 ± 7.0) in asthenopia participants were significantly higher than that of non-asthenopia (p values < 0.001). The area under curve(AUC) in two groups was 0.899 (p value < 0.001). Youden’s index was up to the maximum value 0.784 when the cut-off value was 12.5, and the sensitivity and specificity index were 100% and 78.4%, respectively. Conclusion The new ASQ-17 is an effective assessment tool for asthenopia with an optimal cut-off threshold value 12.5, which is suitable for diagnosis and curative effect evaluation.

Background：Retinitis pigmentosa (RP) patients uauslly complained nyctalopia and poor dark adaptation which caused their visual discomfort, in this study we aimed to explore the effects of a Computer Lens Filter (CLF) on contrast sensitivity (CS), reading speed for computer screen text and visual comfort in subjects with retinitis pigmentosa (RP), and to find wheather CLF would be helpful for RP patients . Method: Twenty-two subjects diagnosed with binocular RP participated. Bright CS using the Mars test and reading speed of screen text were measured using the spectacle corrections for best corrected visual acuity (BCVA) both with and without CLF wear. Subjective estimates of computer screen brightness and visual comfort were evaluated by questionnaire. These functions were compared for the two conditions of filter wear/non-wear. Result： Mean subject age was 38.2±7.5 years and mean log MAR VA was .45± .24. Wearing a CLF neither improved bright CS (t = .452, P=.653) nor increased reading speed (t =.414, P = .683). CLF wear was judged to reduce screen brightness (t = 5.412, P<.0001) and improve visual comfort (t = 6.897, P<.0001). Conclusion： CLF wear neither improved RP subjects’ CS nor reading speed for screen text but did reduce the appearance of screen brightness and improve subjects’ reported visual comfort. Improvement in comfort alone may be sufficient justification for filter use as a vision aid for RP patients during vision rehabilitation.

Background: To measure the corneoscleral limbus and anterior sclera parameters of normal Chinese adults by swept-source optical coherence tomography (OCT). Methods: In this cross-sectional study, a total of 56 Chinese subjects with ametropia were evaluated in the Eye Hospital of Wenzhou Medical University from September 2020 to December 2020, including 26 (46.4%) men, with an average age of 24.7±1.8 years old, and a spherical equivalent of -2.05±0.46 D. The optical coherence tomograph SS-1000 (CASIA, Tomey, Tokyo, Japan) was used to measure the sagittal height, corneoscleral junction angle (CSJ), corneal angle, and scleral angle. One-way analysis of variance and least significant difference test were used to compare the differences in the four segment parameters. Results: The mean sagittal heights of the right eyes at chord lengths of 10.0, 12.3, and 15.0 mm were 1756±72, 2658±110, and 3676±155 μm, respectively. The absolute values of the differences between horizontal and vertical meridians at chord lengths of 10.0, 12.3, and 15.0 mm were 54±40, 70±67, and 117±95 μm, respectively. The differences of CSJ and corneal angles at 12.3 mm chord and scleral angle at 15.0 mm chord in the four segments were statistically significant (F values were 32.01, 21.31, and 13.37, respectively, all P values < 0.001). The CSJ angles from low to high were 176.53±2.14° (nasal), 178.66±1.84° (inferior), 179.13±1.20° (temporal), and 179.31±1.68° (superior), and 87.5% of the nasal angles were less than 179°. The corneal angles at 12.3 mm chord from high to low were 40.31±2.80° (nasal), 39.46±2.41° (temporal), 37.20±2.26° (inferior), and 37.50±2.28° (superior). The scleral angles at 15.0 mm chord from high to low were 38.35±2.47° (temporal), 38.26±3.37° (superior), 35.37±3.10° (nasal), and 35.30±4.71° (inferior). Conclusion: The morphology of corneoscleral limbus and anterior sclera is asymmetrical in normal Chinese adults. The nasal side of the corneoscleral limbus has the largest angle, and the superior and temporal sides of the scleral angle are larger. From the corneoscleral limbus to the anterior sclera, the superior side becomes steep and the other segments become flat.