| Contagious pustular dermatitis (CPD), also known as Orf or contagious ecthyma is an important viral disease of sheep and goats. It is mainly seen as a benign disease but malignant form has also been reported from few parts of the world. The rates of morbidity and mortality are higher, particularly in lambs and kids experiencing the disease for the first time. The causative agent of disease is Orf virus, type species of the genus Parapoxvirus belonging to family Poxviridae. The virus produces localized persistent proliferative skin lesions and affected hosts are infected repeatedly owing to its host immune evasive strategy. These viruses have been found uniformly labile to chloroform but resistant to ether and also exhibit antigenic variations among them. Clinically, the disease is enzootic and occurs in three forms viz. labial, genital / mammary and generalized forms. The incubation period in natural cases is 2-3 weeks. The disease outbreaks mostly occur between autumn and spring but its severity is more in autumn and winter than spring. The virus grows well in cell cultures of caprine, ovine and bovine origin. Confounding symptoms impose laboratory affirmation by serological assays or molecular techniques. The disease can be diagnosed by electron microscopy, serological tests and PCR/ quantitative real-time PCR. Virus specific antibody response to structural proteins of capripox and orf viruses in western-blot analysis readily differentiates these two infections. The antibody response to the 32 kDa and 26 kDa proteins of capripox viruses provides a firm basis for differentiation. Although, the role of humoral immunity is well established but probably cell mediated immunity plays a major role in recovery from natural infections. A number of inactivated and live or live modified vaccines have been tried with variable success. The duration of immunity after vaccination is controversial; outbreaks have occurred in vaccinated animals. The disease is also of public health significance as it causes infection in human beings. Keywords

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Abstract:Motivation is the paramount medium and obligatory precondition that provoke critical thinking among the students. The

Understanding vegetation dynamics is necessary to address potential ecological threats and develop sustainable ecosystem management at high altitudes. In this study, we revealed the spatiotemporal characteristics of vegetation growth in the Lhasa River Basin using net primary productivity (NPP) and normalized difference vegetation index (NDVI) during the period of 2000–2005. The roles of climatic factors and specific anthropogenic activities in vegetation dynamics were also identified, including positive or negative effects and the degree of impact. The results indicated that the interannual series of NPP and NDVI in the whole basin both had a continuous increasing trend from 102 to 128 gC m−2 yr−1 and from 0.417 to 0.489 (p < 0.05), respectively. The strongest advanced trends (>2 gC m−2 yr−1 or >0.005 yr−1) were detected in mainly the southeastern and northeastern regions. Vegetation dynamics were not detected in 10% of the basin. Only 20% of vegetation dynamics were driven by climatic conditions, and precipitation was the controlling climatic factor determining vegetation growth. Accordingly, anthropogenic activities made a great difference in vegetation coverage, accounting for about 70%. The construction of urbanization and reservoir led to vegetation degradation, but the farmland practices contributed the vegetation growth. Reservoir construction had an adverse impact on vegetation within 6 km of the river, and the direct damage to vegetation was within 1 km. The impacts of urbanization were more serious than that of reservoir construction. Urban sprawl had an adverse impact on vegetation within a 6 km distance from the surrounding river and resulted in the degradation of vegetation, especially within a 3 km range. Intensive fertilization and guaranteed irrigation improved the cropland ecosystem conditions, creating a favorable effect on the accumulation of crop organic matter in a range of 5 km, with an NPP trend value of 1.2 gC m−2 yr−1. The highly intensive grazing activity forced ecological environmental pressures such that the correlation between livestock numbers and vegetation growth trend was significantly linear negative.