Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. To identify common PrCa susceptibility alleles, we conducted a multi-stage genome-wide association study and previously reported the results of the first two stages, which identified 16 novel susceptibility loci for PrCa. Here we report the results of stage 3 in which we evaluated 1,536 SNPs in 4,574 cases and 4,164 controls. Ten novel association signals were followed up through genotyping in 51,311 samples in 30 studies through the international PRACTICAL consortium. In addition to previously reported loci, we identified a further seven new prostate cancer susceptibility loci on chromosomes 2p, 3q, 5p, 6p, 12q and Xq (P=4.0 ×10−8 to P=2.7 ×10−24). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ~25% of the familial risk in this disease, have now been identified.

Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10(-8)]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.

AKATSUKI is the Japanese Venus Climate Orbiter that was designed to investigate the climate system of Venus. The orbiter was launched on May 21, 2010, and it reached Venus on December 7, 2010. Thrust was applied by the orbital maneuver engine in an attempt to put AKATSUKI into a westward equatorial orbit around Venus with a 30-h orbital period. However, this operation failed because of a malfunction in the propulsion system. After this failure, the spacecraft orbited the Sun for 5 years. On December 7, 2015, AKATSUKI once again approached Venus and the Venus orbit insertion was successful, whereby a westward equatorial orbit with apoapsis of ~440,000 km and orbital period of 14 days was initiated. Now that AKATSUKI's long journey to Venus has ended, it will provide scientific data on the Venusian climate system for two or more years. For the purpose of both decreasing the apoapsis altitude and avoiding a long eclipse during the orbit, a trim maneuver was performed at the first periapsis. The apoapsis altitude is now ~360,000 km with a periapsis altitude of 1000-8000 km, and the period is 10 days and 12 h. In this paper, we describe the details of the Venus orbit insertion-revenge 1 (VOI-R1) and the new orbit, the expected scientific information to be obtained at this orbit, and the Venus images captured by the onboard 1-µm infrared camera, ultraviolet imager, and long-wave infrared camera 2 h after the successful initiation of the VOI-R1.

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