The photonic spin Hall effect (SHE) in the reflection and refraction at an interface is very weak because of the weak spin-orbit interaction. Here, we report the observation of a giant photonic SHE in a dielectric-based metamaterial. The metamaterial is structured to create a coordinate-dependent, geometric Pancharatnam-Berry phase that results in an SHE with a spin-dependent splitting in momentum space. It is unlike the SHE that occurs in real space in the reflection and refraction at an interface, which results from the momentum-dependent gradient of the geometric Rytov-Vladimirskii-Berry phase. We theorize a unified description of the photonic SHE based on the two types of geometric phase gradient, and we experimentally measure the giant spin-dependent shift of the beam centroid produced by the metamaterial at a visible wavelength. Our results suggest that the structured metamaterial offers a potential method of manipulating spin-polarized photons and the orbital angular momentum of light and thus enables applications in spin-controlled nanophotonics. Keywords: geometric phase; metamaterial; photonic spin Hall effect INTRODUCTION Metamaterials or metasurfaces are artificial materials that are engineered to produce nearly any imaginable optical properties that are not found in nature. 1,2 They are typically structured at the subwavelength scale with ultrathin metallic or dielectric micro/nanoparticles or with holes opened in metallic films. Metamaterials exhibit unprecedented degrees of freedom in the polarization and phase manipulation of light via the geometric structuring of their structural units, especially on the wavelength scale, 3-9 which leads to applications such as vortex beam generators, 3,7 metalenses 10,11 and optical holography. 12,13 These materials also offer considerable potential for the manipulation of the angular moment of light and the photonic spin Hall effect (SHE), thereby providing convenient opportunities for spin-polarized photonics and nanophotonics. [14][15][16][17] The photonic SHE describes the mutual influence of the photon spin (polarization) and the trajectory (orbital angular momentum) of light-beam propagation, i.e., the spin-orbit interaction (SOI), which results in two types of geometric phases: the Rytov-VladimirskiiBerry (RVB) phase and the Pancharatnam-Berry (PB) phase. [18][19][20][21][22] The RVB phase is associated with the evolution of the propagation direction of light. When a light beam reflects/refracts at a planar interface between different media, a SOI occurs, and the corresponding momentum-dependent RVB phase leads to a spin-dependent real-

The recovery process of COVID-19 patients is unclear. Some recovered patients complain of continued shortness of breath. Vasculopathy has been reported in COVID-19, stressing the importance of probing microstructure and function of lungs at the alveolar-capillary interface. While CT detects structural abnormalities, little is known about the impact of disease on lung function. 129Xe MRI is a technique uniquely capable of assessing ventilation, microstructure and gas exchange. Using 129Xe MRI, we found COVID-19 patients have higher ventilation defects percentage (5.9% vs 3.7%), unchanged microstructure, longer gas-blood exchange time (43.5 ms vs 32.5 ms), and reduced RBC/TP (0.279 vs 0.330) compared with healthy subjects. These findings suggest regional ventilation and alveolar airspace dimensions are relatively normal around the time of discharge, while gas-blood exchange function is diminished. This study establishes the feasibility of localized lung function measurement in COVID-19 patients. Such readouts could be useful as a supplement to structural imaging.

Multifunctionalized and branched M-OEGs represent valuable PEGylation agents, linkers, and scaffolds in biomedicine. However, the tedious synthesis limited their availability and application. We herein present an azide reductive dimerization method for the convenient synthesis of aza-M-OEGs and derivatives, which provides easy access to a variety of multifunctionalized and branched M-OEGs in one step. With this method, hexa-arm M-OEGs with 54 symmetrical fluorines were synthesized in two steps as a water-soluble, self-assemble, 19F MRI sensitive, and biocompatible dendritic biomaterial.