In patients with AF, all combinations of warfarin, aspirin, and clopidogrel are associated with increased risk of nonfatal and fatal bleeding. Dual warfarin and clopidogrel therapy and triple therapy carried a more than 3-fold higher risk than did warfarin monotherapy.

Breakthrough cancer pain is an extremely heterogeneous condition.

Background-The majority of out-of-hospital cardiac arrests (OHCAs) occur in residential locations, but knowledge about strategic placement of automated external defibrillators in residential areas is lacking. We examined whether residential OHCA areas suitable for placement of automated external defibrillators could be identified on the basis of demographic characteristics and characterized individuals with OHCA in residential locations. Methods and Results-We studied 4828 OHCAs in Copenhagen between 1994 and 2005. The incidence and characteristics of OHCA were examined in every 100ϫ100-m (109.4ϫ109.4-yd) residential area according to its underlying demographic characteristics. By combining Ն2 demographic characteristics, it was possible to identify 100ϫ100-m (109.4ϫ109.4-yd) areas with at least 1 arrest every 5.6 years (characterized by Ͼ300 persons per area and lowest income) to 1 arrest every 4.3 years (characterized by Ͼ300 persons per area, lowest income, low education, and highest age). These areas covered 9.0% and 0.8% of all residential OHCAs, respectively. Individuals with OHCA in residential locations differed from public ones in that the patients were older (70.6 versus 60.6 years; PϽ0.0001), the ambulance response interval was longer (6.0 versus 5.0 minutes; PϽ0.0001), arrests occurred more often at night (21.2% versus 11.2%; PϽ0.0001), the patients had ventricular fibrillation less often (12.8% versus 38.1%; PϽ0.0001), and the patients had a worse 30-day survival rate (3.2% versus 13.9%; PϽ0.0001). Conclusions-On the basis of simple demographic characteristics of a city center, we could identify residential areas suitable for automated external defibrillator placement. Individuals with OHCA in residential locations were more likely to have characteristics associated with poor outcome compared with public arrests. (Circulation. 2010;122:623-630.)