Thrombotic disease complicates severe SARS-CoV-2 infection 1-3 ; severely elevated D-dimers are a feature of severe COVID-19, even in the absence of identified thrombosis. 4 In an attempt to decrease thrombotic complications in hospitalized patients, intensified prophylactic and full-dose anticoagulation strategies have been evaluated. 1,5,6 The role of chronic anticoagulation before SARS-CoV-2 infection and its potential to ameliorate the risk for subsequent thrombosis has not been systematically studied. 2 | ME THODS This was a retrospective, single-institution study with institutional review board approval. Our search identified all patients with posi

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