Contrasting images: A new T1 contrast agent for magnetic resonance imaging (MRI) based on MnO nanoparticles reveals a bright signal enhancement and fine anatomic structures in the T1‐weighted MR image of a mouse brain (see picture; left MRI, right MnO‐enhanced MRI (MONEMRI)). Furthermore, MnO nanoparticles conjugated with a tumor‐specific antibody were used for selectively imaging breast cancer cells in a metastatic tumor in brain.
Kontrastreich: Ein T1‐Kontrastmittel für die Kernspintomographie (MRI), das auf MnO‐Nanopartikeln beruht, bewirkt eine große Signalverstärkung und macht aufgelöste anatomische Strukturen im T1‐gewichteten MR‐Bild eines Maushirns sichtbar (siehe Bild; links: MRI, rechts: MnO‐verstärkte MRI (MONEMRI)). Mit einem tumorspezifischen Antikörper konjugierte MnO‐Nanopartikel wurden zudem genutzt, um Brustkrebszellen in einer Metastase im Hirn selektiv abzubilden.
Buprederm was shown to be efficacious by achieving the effective buprenorphine concentration in the blood and brain sufficient to maintain an analgesic effect for 72 h, and was also shown to be safe following multiple applications.
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