Background The impact of SARS-CoV-2 infection on the gut fungal (mycobiota) and bacterial (microbiota) communities has been elucidated individually. This study analyzed both gut mycobiota and microbiota and their correlation in the COVID-19 patients with severe and mild conditions and follow-up to monitor their alterations after recovery. Methods We analyzed the gut mycobiota and microbiota by bacterial 16S and fungal ITS1 metagenomic sequencing of 40 severe patients, 38 mild patients, and 30 healthy individuals and reanalyzed those of 10 patients with severe COVID-19 approximately 6 months after discharge. Results The mycobiota of the severe and mild groups showed lower diversity than the healthy group, and in some, characteristic patterns dominated by a single fungal species, Candida albicans, were detected. Lower microbial diversity in the severe group was observed, but no differences in its diversity or community structure were detected between the mild and healthy groups. The microbiota of the severe group was characterized by an increase in Enterococcus and Lactobacillus, and a decrease in Faecalibacterium and Bacteroides. The abundance of Candida was positively correlated with that of Enterococcus in patients with COVID-19. After the recovery of severe patients, alteration of the microbiota remained, but the mycobiota recovered its diversity comparable to that of mild and healthy groups. Conclusion In mild cases, the microbiota is stable during SARS-CoV-2 infection, but in severe cases, alterations persist for 6 months after recovery.

A remarkably simple synthesis of [7]circulene 1 via an ethano‐bridged hexahelicene intermediate is described. Cyclic voltammetry reveals that 1 is easier to oxidize and reduce than coronene. The results of ab initio calculations for coronene, 1, and its radical ions are consistent with the experimental findings.

Die jungsten Fortschritte in der Chemie der Kohlenstoff-Cluster (Fullerene) haben das Interesse an nichtplanaren, polycyclischen aromatischen Verbindungen rnit kreisformig angeordneten Benzolringen, den Circulenen ['], wieder verstarkt. Wir haben kiirzlich iiber die Synthese von [7]Circulen 11L2] (Pleiadann~len)[~I berichtet, dessen verdrillte, sattelformige Struktur, die sich aus den zu einem Siebenring angeordneten Kohlenstoffringen ergibt, als eine Untereinheit der inneren Oberflache einer helixformigen Nanorohre gesehen werden kann14]. Wir beschreiben nun eine bequeme Alternativsynthese von l l uber das 2,15-Ethano-verbriickte Hexahelicen 9 und die elektrochemischen Eigenschaften von 11.Die Wittig-Reaktion von 2,7-Naphthalindicarboxaldehyd 1 rnit Triphenyl-para-xylylphosphoniumbromid in Natriummethanolat/DMF fiihrte zu einem Gemisch der Stereoisomere 2. Dieses Gemisch wurde in Benzol gelost und 2 h mit einer Hochdruck-Quecksilberlamper6] bestrahlt, wodurch 2,15-Dimethylhexahelicen 3 entstand (Schmp. 212-214 "C, 59 % Ausbeute bezogen auf l) [']. Die Bromierung von 3 rnit N-Bromsuccinimid ergab das Dibromid 4 40%)

No abstract

The polycyclic aromatic compound with a S-shaped circular arrangement of seven benzene rings, hepta[5][5]circulene 11, was prepared by FVP of bis(1-chlorovinyl)acenaphthofluoranthene 9. The structure and electrochemical properties were also reported.