, U. hopp 5,6 , C. Haumea-one of the four known trans-Neptunian dwarf planetsis a very elongated and rapidly rotating body 1-3 . In contrast to other dwarf planets [4][5][6] , its size, shape, albedo and density are not well constrained. The Centaur Chariklo was the first body other than a giant planet known to have a ring system 7 , and the Centaur Chiron was later found to possess something similar to Chariklo's rings 8,9 . Here we report observations from multiple Earth-based observatories of Haumea passing in front of a distant star (a multichord stellar occultation). Secondary events observed around the main body of Haumea are consistent with the presence of a ring with an opacity of 0.5, width of 70 kilometres and radius of about 2,287 kilometres. The ring is coplanar with both Haumea's equator and the orbit of its satellite Hi'iaka. The radius of the ring places it close to the 3:1 mean-motion resonance with Haumea's spin period-that is, Haumea rotates three times on its axis in the time that a ring particle completes one revolution. The occultation by the main body provides an instantaneous elliptical projected shape with axes of about 1,704 kilometres and 1,138 kilometres. Combined with rotational light curves, the occultation constrains the three-dimensional orientation of Haumea and its triaxial shape, which is inconsistent with a homogeneous body in hydrostatic equilibrium. Haumea's largest axis is at least 2,322 kilometres, larger than previously thought, implying an upper limit for its density of 1,885 kilograms per cubic metre and a geometric albedo of 0.51, both smaller than previous estimates 1, 10,11 . In addition, this estimate of the density of Haumea is closer to that of Pluto than are previous estimates, in line with expectations. No global nitrogen-or methane-dominated atmosphere was detected.Within our programme of physical characterization of trans-Neptunian objects (TNOs), we predicted an occultation of the star URAT1 533− 182543 by the dwarf planet (136108) Haumea and arranged observations as explained in Methods. Positive occultation detections were obtained on 2017 January 21, from twelve telescopes at ten different observatories. The instruments and the main features of each station are listed in Table 1.As detailed in Methods (see also Fig. 1), the light curves (the normalized flux from the star plus Haumea versus time) show deep 1 2

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Pluto and Eris are icy dwarf planets with nearly identical sizes, comparable densities and similar surface compositions as revealed by spectroscopic studies 1,2 . Pluto possesses an atmosphere whereas Eris does not; the difference probably arises from their differing distances from the Sun, and explains their different albedos 3 . Makemake is another icy dwarf planet with a spectrum similar to Eris and Pluto 4 , and is currently at a distance to the Sun intermediate between the two. Although Makemake's size (1,420 6 60 km) and albedo are roughly known 5,6 , there has been no constraint on its density and there were expectations that it could have a Plutolike atmosphere 4,7,8 . Here we report the results from a stellar occultation by Makemake on 2011 April 23. Our preferred solution that fits the occultation chords corresponds to a body with projected axes of 1,430 6 9 km (1s) and 1,502 6 45 km, implying a V-band geometric albedo p V 5 0.77 6 0.03. This albedo is larger than that of Pluto, but smaller than that of Eris. The disappearances and reappearances of the star were abrupt, showing that Makemake has no global Pluto-like atmosphere at an upper limit of 4-12 nanobar (1s) for the surface pressure, although a localized atmosphere is possible. A density of 1.7 6 0.3 g cm 23 is inferred from the data. Stellar occultations allow detection of very tenuous atmospheres and can provide accurate sizes and albedos 9,10,11,3,12 , so we embarked on a programme of predicting and observing occultations by (136472) Makemake, also known as 2005 FY 9 . The occultation of the faint star NOMAD 1181-0235723 (with magnitude m R 5 18.22, where NOMAD is the Naval Observatory Merged Astronomic Dataset) was predicted in 2010 by methods similar to those used to predict occultations by several large bodies 13 , but refined as shown in Supplementary Information section 1. We arranged a campaign involving 16 telescopes, listed in Supplementary Table 1. The occultation was successfully recorded from seven telescopes, listed in Table 1, at five sites. From the images obtained, we made photometric measurements as a function of time (light curves).The light curves of the occultation are shown in Fig. 1. Fitting synthetic square-well models to the light curves yielded the disappearance and reappearance times of the star (Table 1), from which we calculate one chord in the plane of the sky for each site (see Supplementary Information section 3). On the basis of analyses of the light curves, taking into account the cycle time between the images and the dispersion of the data, we deduce that there were no secondary occultations, so we can reject the existence of a satellite larger than about 200 km in diameter in the areas sampled by the chords. The result is consistent with a deep-image survey that did not find any satellites 16 . The chords can be fitted with two shape models (Fig. 2). Our preferred shape, which is compatible with our own and other observations (see Supplementary Information section 8), corresponds to an elliptical object ...

The Middle East is a culturally and politically diverse region at the gateway between Europe, Africa and Asia. Spatial dynamics of the fatal zoonotic disease rabies among countries of the Middle East and surrounding regions is poorly understood. An improved understanding of virus distribution is necessary to direct control methods. Previous studies have suggested regular trans-boundary movement, but have been unable to infer direction. Here we address these issues, by investigating the evolution of 183 rabies virus isolates collected from over 20 countries between 1972 and 2014. We have undertaken a discrete phylogeographic analysis on a subset of 139 samples to infer where and when movements of rabies have occurred. We provide evidence for four genetically distinct clades with separate origins currently circulating in the Middle East and surrounding countries. Introductions of these viruses have been followed by regular and multidirectional trans-boundary movements in some parts of the region, but relative isolation in others. There is evidence for minimal regular incursion of rabies from Central and Eastern Asia. These data support current initiatives for regional collaboration that are essential for rabies elimination.

Background: The potential role of oral vaccination of dogs against rabies in the Philippines was investigated in terms of safety and efficacy.