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Summary Patinent multi-omics datasets are often characterized by a high dimensionality, however usually only for a small fraction of the features is informative, that is changes in their values is directly related to the disease outcome or patient survival. In medical sciences, in addition to a robust feature selection procedure, the ability to discover human-readable patterns in the analysed data is also desirable. To address this need, we created MAINE—Multi-omics Analysis and Exploration. The unique functionality of MAINE is the ability to discover multidimensional dependencies between the selected multi-omics features and event outcome prediction as well as patient survival probability. Learned patterns are visualized in the form of interpretable decision/survival trees and rules. Availability MAINE is freely available at maine.ibemag.pl as an online web application. Supplementary information Supplementary data are available at Bioinformatics online.

Automatic translation between the national language and sign language is a complex process similar to translation between two different foreign languages. A very important aspect is the precision of not only manual gestures but also facial expressions, which are extremely important in the overall context of a sentence. In this article, we present the problem of including facial expressions in the automation of Polish-to-Polish Sign Language (PJM) translation—this is part of an ongoing project related to a comprehensive solution allowing for the animation of manual gestures, body movements and facial expressions. Our approach explores the possibility of using action unit (AU) recognition in the automatic annotation of recordings, which in the subsequent steps will be used to train machine learning models. This paper aims to evaluate entropy in real-life translation recordings and analyze the data associated with the detected action units. Our approach has been subjected to evaluation by experts related to Polish Sign Language, and the results obtained allow for the development of further work related to automatic translation into Polish Sign Language.

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