Background: The beginning of 2020 was characterized by the COVID-19 pandemic. The world governments have adopted restrictive measures to reduce the spread of infection. These measures could affect the sexual function and quality of life of women living with their partner. Aim: The aim is to assess the impact of the social distancing measures caused by the COVID-19 pandemic on sexual function and quality of life of noninfected reproductive-age women, living with their sexual partner. Methods: Observational analysis on sexually active women, living with their partner, and without COVID-19 infection was performed. The population previously answered FSFI, FSDS, and SF-36 questionnaires. 4 weeks after the introduction of the restrictive measures, these women were invited to complete the same questionnaires by e-mail for an evaluation during the COVID-19 outbreak. Main Outcome Measures: The primary endpoint was the assessment of the women's sex function change during the social restriction period, by analyzing the FSFI and FSDS questionnaires. The secondary endpoint was the evaluation of the impact on the quality of life calculated by the SF-36 questionnaire. Results: 89 patients were considered. The median age was 39 (28e50) years. Mean sexual intercourses/month decreased from 6.3 ± 1.9 to 2.3 ± 1.8, mean difference: À3.9 ± 1.2. FSFI decreased significantly (29.2 ± 4.2 vs 19.2 ± 3.3, mean difference: À9.7 ± 2.6) and FSDS increased significantly (9.3 ± 5.5 vs 20.1 ± 5.2, mean difference: 10.8 ± 3.4). The SF-36 showed a significant change from 82.2 ± 10.2 to 64.2 ± 11.8 4 weeks after the introduction of the restrictive measures; mean difference: À17.8 ± 6.7. The univariable analysis identified working outside the home, university educational level, and parity !1 as predictive factors of lower FSFI. In multivariable analysis, working outside the home and combination of working outside the home þ university educational level þ parity !1 were the independent factors of a lower FSFI. Clinical Implication: The negative impact of the COVID-19 epidemic period on sexual function and quality of life in women shows how acute stress might affect the psychological state. Thus, psychological or sexual support could be useful. Strengths and Limitations: To our knowledge, this study is the first that analyzes the change in sexual activity in women during the COVID-19 outbreak period. The limitations were the low number of the analyzed participants, psychological tests were not included, and no data were collected on masturbation, self-heroism, solitary, and nonpenetrative sex. Conclusion:The COVID-19 epidemic and the restrictive social distancing measures have negatively influenced the sexual function and quality of life in not-infected reproductive-age women who live with their sexual partners.

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IntroductionBrenner tumor of the ovary is a relatively uncommon neoplasm. It constitutes about 1.5% of all ovarian tumors and has a predilection for post-menopausal woman, with a peak of incidence in the fifth decade (1-3).These tumors are mainly asymptomatic and in case of small lesions they may be incidentally detected (2). Conversely non pathognomonic clinical symptoms, like pelvic palpable mass or abdominal pain, occur only for larger tumors (1). No screening tests or markers for MBTS exist. Different pathological variants exist: the benign, borderline and malignant types.The vast majority of these neoplasms is benign, while only 1% is malignant. This latter type is often bilateral, constituted by a mixture of solid and cystic tissues, and represents an aggressive form (4) associated with a poor prognosis (5).Diagnosis is made with histological examination and surgery remains the mainstay of treatment (6).Due to the rarity of this malignancy, there are few cases of metastatic MBT described in literature, most including liver and lung metastases (2), dural metastases (7), subcutaneous (8) and cutaneous (9) metastases. Nevertheless non-unanimous consensus is given on which is the best adjuvant treatment (6).Here we present a case of a malignant Brenner tumor of the ovary which metastasized to brain, lung and liver, concomitant with endometroid adenocarcinoma of the uterus in a 46-year-old woman. Materials and methodsA 46-year-old Caucasian woman presented at our emergency room for abnormal uterine bleeding and a Introduction. Brenner tumor of the ovary represents an uncommon neoplasm. It constitutes about 1.5% of all ovarian tumors with a peak of incidence in the fifth decade. The vast majority of Brenner tumors is benign, while only 1% is malignant and associated with a poor prognosis. Diagnosis could be made only with histological examination, and surgery is the mainstay of treatment.Materials and methods. Brain metastases from malignant Brenner tumor of the ovary: a case report and a literature review

A systematic immunohistochemistry should be a key step in the therapeutic algorithm and could contribute to the identification of high-risk tumors.

Ospemifene is an effective potential therapy for postmenopausal women with VVA improving OAB symptoms and quality of life.