Purpose: Paclitaxel shows little benefit in the treatment of glioma due to poor penetration across the blood-brain barrier (BBB). Low intensity pulsed ultrasound (LIPU) with microbubble injection transiently disrupts the BBB allowing for improved drug delivery to the brain. We investigated the distribution, toxicity and efficacy of LIPU delivery of two different formulations of paclitaxelalbumin-bound paclitaxel (ABX) and paclitaxel dissolved in cremophor (CrEL-PTX)-in preclinical glioma models. Experimental Design: The efficacy and biodistribution of ABX and CrEL-PTX were compared with and without LIPU delivery. Anti-glioma activity was evaluated in nude mice bearing intracranial patient-derived glioma xenografts (PDX). PTX biodistribution was determined in sonicated and non-sonicated nude mice. Sonications were performed using a 1 MHz LIPU device §

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