Selenium (Se) has been suggested to be beneficial to obesity development. However, limited studies have evaluated the association between Se and childhood obesity and the findings are inconsistent.The aim of this study was to examine the association of Se levels with obesity in children in a cross-sectional study.A total of 62 obese (21 girls) and 65 normal-weight children (27 girls) aged 7 to 13 years were recruited in Shanghai, China. Obesity was defined as body mass index (BMI) ≥ its 95th age- and sex-specific percentile for children. Participant demographic data and parental information were obtained through a self-administered questionnaire. Se concentration in fingernail clippings was quantified using flame atomic absorption spectrophotometry.The average age was 10.9 years (standard deviation = 1.0) and the mean BMI was 21.2 kg/m2 (standard deviation = 5.0). Fingernail Se levels were relatively higher among normal-weight children as compared with obese participants, though the difference was not statistically significant (P = .79). Se levels were inversely associated with the risk of childhood obesity after adjustment for potential confounders. The multivariable-adjusted odds ratio (95% confidence interval) was 0.24 (0.07–0.84) comparing participants in the highest with those who in the lowest tertile of Se levels (Plinear-trend = .03).Our study supported an inverse association between fingernail Se levels and the risk of obesity in Chinese children. Data generated from the present study are useful for designing future prospective cohort studies and/or randomized clinical trials.

Abstract Background We performed a cohort study to evaluate the association between the CRP trajectory and incident diabetes in Chinese adults. Methods Included were 6,439 adults (4,111 men and 2,249 women; aged 46.6±11.9 years). The concentration of high sensitivity CRP (hs-CRP) was measured in 2013 (baseline), 2014, and 2015. The hs-CRP trajectory was identified based the above three measurements by latent mixture modeling. Incident diabetes cases were diagnosed by fasting blood glucose (≥126mg/dl) or Hb A1c (≥6.5%) during subsequent three years (2016-2018). Results Hs-CRP level during 2013 -2015 was classified into 3 levels: low (<1.0 mg/L), moderate (1.0–3.0 mg/L), and high (≥3.0 mg/L) based on a statement by American Heart Association. We named four hs-CRP trajectories as following: “low-stable” (low in 2013 and maintained at low level in 2014 and 2015), “moderate-fluctuated” (moderate in 2013, then increased to high level in 2014, and decreased to low level in 2015), “high-decreased” (high in 2013 but decreased to moderate level in 2014 and 2015), and “moderate-increased (moderate in 2013 and increased to high level in 2014 and 2015)”. We identified 235 incident diabetes during subsequent three years. The adjusted HR for incident diabetes was 1.71 (95% CI: 1.02, 2.87) comparing the moderate-increased and the low-stable group, after adjusting for potential confounders. In the secondary analyses, baseline hs-CRP level and the average of hs-CRP were associations between higher hs-CRP concentration and higher diabetes risk were observed (P-trend<0.01 for both). Conclusions The hs-CRP trajectory pattern was associated with altered incident diabetes in Chinese adults.

ObjectivesPrevious studies reported that overweight older adults had a lower mortality after cardiovascular diseases attack, indicating being thinner might not always be better. However, there is ongoing debate about what is the optimal range of body mass index (BMI) for the aged population. We aimed to evaluate the value of BMI for the prediction of incident diabetes mellitus (DM) in Chinese elderly population.MethodsA total number of 6,911 Chinese elderly people (4,110 men and 2,801 women, aged 71±6.0 years) were included in this cohort study. BMI was measured at baseline (Jan 1st 2014 to Dec 31st 2014). All the participants were further classified into six groups: < 18.5kg/m2, 18.5 to < 22.5 kg/m2, 22.5 to < 25.0 kg/m2, 25.0 to < 27.5 kg/m2, 27.5 to < 30.0 kg/m2, and ≥ 30.0 kg/m2. Fasting blood glucose (FBG) and glycated hemoglobin A1c (HbA1c) were annually measured during follow-up (Jan 1st 2015-May 31st 2019). DM was confirmed if either FBG ≥ 7.0 mmol/L or HbA1c ≥ 6.5%. We used the Cox proportional hazards regression model to evaluate the association between BMI and the prediction of incident DM. ResultsComparing individuals with a BMI range of 18.5 to < 22.5 kg/m2 (reference), the hazards ratio for incident DM was 2.13 (95% CI: 1.54~2.95), 2.14 (95% CI: 1.53~3.00), 3.17 (95% CI: 2.19~4.59), 3.15 (95% CI: 1.94~5.09), and 3.14 (95% CI: 1.94~5.09) for the group with a BMI range of 22.5 to < 25.0 kg/m2, 25.0 to < 27.5 kg/m2, 27.5 to < 30.0 kg/m2, and ≥ 30.0 kg/m2 after adjusting for baseline age, sex, blood pressure, lipid profiles, and eGFR (P trend <0.001), after adjusting for the above-mentioned confounders. The association tended to be closer in men and young participants, compared with their counterparts.ConclusionsHigh BMI was associated with high risk of developing DM in Chinese aged population. Thus, it is optimal for the aged population to maintain their body weight within a reasonable range to prevent chronic diseases.