HighlightsCircACTN4 was upregulated in ICC and is associated with a worse prognosis.CircACTN4 promoted ICC growth and metastasis in vitro and in vivo.CircACTN4 recruited YBX1 to initiate FZD7 transcription.CircACTN4 acted as sponge of miR-424-5p to upregulate YAP1.CircACTN4 enhanced the interaction between the Wnt/b-catenin and Hippo/YAP pathways.
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