There has recently been a dramatic renewal of interest in hadron spectroscopy and charm physics. This renaissance has been driven in part by the discovery of a plethora of charmonium-like XYZ states at BESIII and B factories, and the observation of an intriguing proton-antiproton threshold enhancement and the possibly related X(1835) meson state at BESIII, as well as the threshold measurements of charm mesons and charm baryons. We present a detailed survey of the important topics in tau-charm physics and hadron physics that can be further explored at BESIII during the remaining operation period of BEPCII. This survey will help in the optimization of the data-taking plan over the coming years, and provides physics motivation for the possible upgrade of BEPCII to higher luminosity.

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Immune checkpoint blockers (ICBs) have shown great promise at harnessing immune system to combat cancer. However, only a fraction of patients can directly benefit from the anti–programmed cell death protein 1 (aPD1) therapy, and the treatment often leads to immune-related adverse effects. In this context, we developed a prodrug hydrogelator for local delivery of ICBs to boost the host’s immune system against tumor. We found that this carrier-free therapeutic system can serve as a reservoir for extended tumoral release of camptothecin and aPD1 antibody, resulting in an immune-stimulating tumor microenvironment for boosted PD-1 blockade immune response. Our in vivo results revealed that this combination chemoimmunotherapy elicits robust and durable systemic anticancer immunity, inducing tumor regression and inhibiting tumor recurrence and metastasis. This work sheds important light into the use of small-molecule prodrugs as both chemotherapeutic and carrier to awaken and enhance antitumor immune system for improved ICBs therapy.

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Solar vapor generation is a facile and an efficient way for solar energy harvesting, which is applied to address the issue of fresh water extraction from sewage or brine. Several solar vapor generation devices have been developed in the past few years, but the low evaporation rate still remains as a challenge. In this work, a novel double-layer solar vapor generation device, named as Ag-PSS-AG/AG device, is reported. This device is based on the hierarchical composition of silver nanoparticles (Ag NPs) and poly (sodiump-styrenesulfonate) (PSS) decorated agarose gel (AG). The device reveals a synergetic effect of the two layers with high light-harvesting and watertransfer performance, respectively, leading to an ultrahigh vapor generation rate of 2.10 kg m −2 h −1 with a solar thermal efficiency of 92.8% under 1 sun illumination. This high evaporation rate is mainly owing to the powerful light-thermal conversion of Ag NPs as well as the outstanding water transfer capability of agarose hydrogel. Consequently, this device can be directly used for the purification of sewage and muddy water. It is also promising for applications in separation, humidity management, and others.NPs embedded in AG skeleton ensures the adequate transfer and full utilization of the converted heat energy. Therefore, the Ag-PSS-AG/AG device exhibits an ultrahigh vapor generation rate of 2.10 kg m −2 h −1 with a solar thermal efficiency of 92.8% under 1 sun illumination.