2 ФГБОУ ВО «Северный государственный медицинский университет» Минздрава России, Архангельск 3 Федеральное государственное автономное бюджетное образовательное учреждение высшего профессионального образования «Российский университет дружбы народов» (РУДН), Москва 4 ФГБОУ ВО «Московский государственный университет им. М. В. Ломоносова», Москва 5 ФГБОУ ВО «Ивановская государственная медицинская академия» Минздрава России, Иваново 6 ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России, Самара 7 ФГБОУ ВО «Кемеровский государственный медицинский университет» Минздрава России, Кемерово Дефицит магния и гиперкоагуляционные состояния: метрический анализ данных выборки пациентов 18-50 лет лечебно-профилактических учреждений России Ключевые слова: уровни магния в плазме крови, пищевое потребление магния, поперечные («кросс-секционные») исследования, интеллектуальный анализ данных, взрослые.

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Given the observable toxicity of lithium carbonate, neuropharmacology requires effective and non-toxic lithium salts. In particular, these salts can be employed as neuroprotective agents since lithium ions demonstrate neuroprotective properties through inhibition of glycogen synthetase kinase-3β and other target proteins, increasing concentrations of endogenous neurotrofic factors. The results of theoretical and experimental studies of organic lithium salts presented here indicate their potential as neuroprotectors. Chemoreactomic modeling of lithium salts made it possible to select lithium ascorbate as a suitable candidate for further research. A neurocytological study on cerebellar granular neurons in culture under conditions of moderate glutamate stress showed that lithium ascorbate was more effective in supporting neuronal survival than chloride or carbonate, i.e., inorganic lithium salts. Biodistribution studies indicated accumulation of lithium ions in a sort of “depot”, potentially consisting of the brain, aorta, and femur. Lithium ascorbate is characterized by extremely low acute and chronic toxicity (LD50 > 5000 mg/kg) and also shows a moderate antitumor effect when used in doses studied (5 or 10 mg/kg). Studies on the model of alcohol intoxication in rats have shown that intake of lithium ascorbate in doses either 5, 10 or 30 mg/kg did not only reduced brain damage due to ischemia, but also improved the preservation of myelin sheaths of neurons.

Hepatoprotectors are necessary for the treatment of alcoholic and non-alcoholic (including medicinal) liver damage. This paper presents the results of a study of the Laennec hepatoprotector, produced on the basis of pharmaceutically standardized human placental hydrolysates (HPH). The use of HSP in toxic liver damage with alcohol or paracetamol led to a significant decrease in markers of liver dysfunction (AST, ALT, bilirubin, MDA), which increase when the models are reproduced. The hepatoprotective effect of Laennec was confi rmed by the results of histological studies, indicating a reduction in infl ammation and preservation of the liver parenchyma. Histological studies also indicated the nephroprotective and cardioprotective effects of Laennec in liver damage with both alcohol and paracetamol.