008 PPARγ regulates IL-9 expression in human TH2 cells by promoting glycolysis

Meyenn, Leonhard von; Steck, Oliver; Friedli, Olivier; Bertschi, Nicole; Freigang, Stefan; Schlapbach, Christoph

doi:10.1016/j.jid.2019.07.011

Cited by 1 publication

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“…Furthermore, PPAR-γ influences both Th2 cells and ILC2 metabolic programs. In T cells, PPAR-γ regulates IL-9 production ( Micossé et al, 2019 ) and promotes glycolysis ( von Meyenn et al, 2019 ) while in ILC2s, PPAR-γ supports IL-33–mediated ILC2 pro-tumoral functions by increasing IL-13 secretion ( Ercolano et al, 2021 ). Moreover, PPAR-γ and diacylglycerol acyltransferase 1 (DGAT1) promotes the accumulation and storage of lipids in ILC2 within droplets to promote ILC2 proliferation ( Karagiannis et al, 2020 ).…”

Section: Helper Adaptive and Innate Lymphocyte Subsets: Cd4 ...mentioning

confidence: 99%

Metabolic features of innate lymphoid cells

Jacquelot

Belz

2022

Journal of Experimental Medicine

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Innate and adaptive immune cells are found in distinct tissue niches where they orchestrate immune responses. This requires intrinsic and temporal metabolic adaptability to coordinately activate the immune response cascade. Dysregulation of this program is a key feature of immunosuppression. Direct or indirect metabolic immune cell reprogramming may offer new approaches to modulate immune cells behavior for therapy to overcome dysregulation. In this review, we explored how metabolism regulates lymphocytes beyond the classical T cell subsets. We focus on the innate lymphoid cell (ILC) family, highlighting the distinct metabolic characteristics of these cells, the impact of environmental factors, and the receptors that could alter immune cell functions through manipulation of metabolic pathways to potentially prevent or treat various diseases.

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Section: Helper Adaptive and Innate Lymphocyte Subsets: Cd4 ...mentioning

confidence: 99%