009 Histological Characterization of Periurethral Tissue: Potential Role in Sexual Function

Clohosey, Diandra; Gaudet, D.; Goldstein, S.; Komisaruk, Barry R.; Szell, N.; Hannan, Johanna L.; Kawaja, Michael D.; Ghasemlou, Nader; MacKenzie, Leslie; Goldstein, Irwin; Adams, Michael

doi:10.1016/j.jsxm.2017.11.028

Cited by 1 publication

(2 citation statements)

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“…The periurethral region is a surrogate marker of periurethral glandular tissue, which contributes to the normal urethral secretion and homeostatic anti-microbial effect. A cadaveric study by Clohosey et al [15] revealed that periurethral space has several PAS-positive mucus glands, nerves, and blood vessels. The secretions of para-urethral glands were suggested to play a role in prevention of urinary tract infection [7,8].…”

Section: Discussionmentioning

confidence: 99%

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Estimation of dose-volume parameters of female urethra as organ-at-risk during interstitial brachytherapy in gynecological malignancies

Radhakrishna

Palled

Pasha

et al. 2021

jcb

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Purpose: Interstitial brachytherapy (ISBT) is often used as post-external beam radiotherapy (EBRT) to treat locally advanced gynecological malignancies. Female urethra is in close proximity to the target during ISBT. However, it has not been evaluated as an organ-at-risk (OAR). Overlapping symptoms caused by radiation-induced bladder toxicity vs. urethral toxicity make it difficult to identify and report urethral toxicities separately. This was a retrospective study to estimate dose-volume parameters of female urethra during high-dose-rate ISBT.Material and methods: Data of 24 patients with gynecological malignancies treated by ISBT were selected. Urethra and periurethral regions were retrospectively contoured. Mean volume, D max , D mean , D 2cc , D 1cc , D 0.5cc , D 0.2cc , and D 0.1cc were documented. Unpaired t-test was used for comparison of means.Results: 20/24 Ca. cervix, 1/24 Ca. vagina, and 3/24 Ca. vaginal vault received 6-6.5 Gy in 4 ISBT fractions. Mean urethral length was 3.54 ±0.55 cm. Mean doses received by urethra per BT fraction were D max = 4.23 ±1.32 Gy, D mean = 2.71 ±1.01 Gy, D 0.2cc = 3.31 ±1.07, and D 0.1cc = 3.54 ±1.09 Gy. Comparison of total BT 2 Gy equivalent dose (EQD 2 ) with 4 fractions for urethra between patients with (9/24) and without anterior vaginal wall (15/24) involvement included D mean

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Section: Discussionmentioning

confidence: 99%

“…A cadaveric study by Clohosey et al . [ 15 ] revealed that periurethral space has several PAS-positive mucus glands, nerves, and blood vessels. The secretions of para-urethral glands were suggested to play a role in prevention of urinary tract infection [ 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%