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Shiraki, Kunihiko; Moriwaki, Mitsuyasu; Kohno, Takeya; Yanagihara, Nobuyo; Miki, Tokuhiko

doi:10.1023/a:1026571327117

Cited by 19 publications

(9 citation statements)

References 17 publications

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“…Ischemia and delays in filling choriocapillaris can lead to early hypofluorescent spots[3,18,19,20]. In this study, the late phase choroidal non-perfusion regions detected by ICGA were significantly associated with DR severity.…”

Section: Discussionmentioning

confidence: 54%

Imaging Evidence of Diabetic Choroidopathy In Vivo: Angiographic Pathoanatomy and Choroidal-Enhanced Depth Imaging

et al. 2013

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PurposeTo describe the pathoanatomy of diabetic choroidopathy (DC) in pre-diagnosed diabetic retinopathy (DR) cases and to provide angiographic and optical evidence for DC using indocyanine green angiography (ICGA) and enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT). MethodsA retrospective analysis of 80 eyes from 40 DR patients was conducted. In Group One, choroidal vascular abnormalities were evaluated by comparing angiographic findings from simultaneous ICGA with those from fundus fluorescein angiography (FFA). In Group Two, EDI SD-OCT was used to evaluate the subfoveal choroidal thickness (SFCT) and define the choroid boundary in order to acquire the bilateral and symmetric choroidal area (CA). Data were then analyzed by Image Pro Plus 6.0. ResultsIn Group One, choroidal abnormalities that were evident using ICGA but not FFA included early hypofluorescent spots in 47 eyes (75.81%), late hyperfluorescent spots in 37 eyes (59.68%), and late choroidal non-perfusion regions in 32 eyes (51.61%). In particular, a significant difference between proliferative DR (PDR) in 17 of 23 eyes (73.91%) and non-PDR in 16 of 39 eyes (41.03%) was observed in late choroidal non-perfusion regions. Eighteen of 31 eyes (58.06%) also exhibited “inverted inflow phenomena.” In Group Two, both the SFCT and CA of eyes with diabetic macular edema and serous macular detachment were significantly greater than those in the other eyes. The CA in panretinal photocoagulation (PRP) treated cases was also greater than that in non-PRP treated cases. ConclusionsEarly hypofluorescent spots, late choroidal non-perfusion regions, inverted inflow phenomena, higher SFCT, and larger CA are qualitative and quantitative indexes for DC. Moreover, the late choroidal non-perfusion region is a risk factor for DC with DR. Our study suggests that the supplemental use of ICGA and EDI SD-OCT with FFA is a better choice for DR patients.

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Section: Discussionmentioning

confidence: 54%

Imaging Evidence of Diabetic Choroidopathy In Vivo: Angiographic Pathoanatomy and Choroidal-Enhanced Depth Imaging

et al. 2013

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“…However, studies on vascular filling of the choroidal vessels suggest that choroidal angiopathy may also be involved. Delayed choroidal vascular filling, which manifests as choroidal hypofluorescence on ICG, is observed in eyes affected with diabetic retinopathy, and correlates with the severity of disease [41-47]. Using SD-OCT, analysis of choroidal thickness in eyes affected with diabetic retinopathy has been performed [Fig.…”

Section: Present Applications Of Optical Coherence Tomographymentioning

confidence: 99%

Optical coherence tomography – current and future applications

Adhi

Duker

2013

Current Opinion in Ophthalmology

499

326

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Purpose of review Optical coherence tomography (OCT) has revolutionized the clinical practice of ophthalmology. It is a noninvasive imaging technique that provides high-resolution, cross-sectional images of the retina, retinal nerve fiber layer and the optic nerve head. This review discusses the present applications of the commercially available spectral-domain OCT (SD-OCT) systems in the diagnosis and management of retinal diseases, with particular emphasis on choroidal imaging. Future directions of OCT technology and their potential clinical uses are discussed. Recent findings Analysis of the choroidal thickness in healthy eyes and disease states such as age-related macular degeneration, central serous chorioretinopathy, diabetic retinopathy and inherited retinal dystrophies has been successfully achieved using SD-OCT devices with software improvements. Future OCT innovations such as longer-wavelength OCT systems including the swept-source technology, along with Doppler OCT and en-face imaging, may improve the detection of subtle microstructural changes in chorioretinal diseases by improving imaging of the choroid. Summary Advances in OCT technology provide for better understanding of pathogenesis, improved monitoring of progression and assistance in quantifying response to treatment modalities in diseases of the posterior segment of the eye. Further improvements in both hardware and software technologies should further advance the clinician’s ability to assess and manage chorioretinal diseases.

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“…Delayed choroidal vascular filling, which appears as choroidal hypofluorescence on indocyanine green angiography (2-4), has been demonstrated in the eyes of humans with diabetes mellitus and shown to correlate with the severity of DR (2,5-8). Laser Doppler flowmetry studies show a reduction in choroidal blood flow and volume in patients with nonproliferative (NPDR) and proliferative DR (PDR) (9).…”

Section: Introductionmentioning

confidence: 99%

Analysis of Morphological Features and Vascular Layers of Choroid in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography

et al. 2013

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Abstract: Scattered hypofluorescent spots seen in the posterior pole during the late-phase of ICG angiograms can apparently be due to aging of the fundus.

Cited by 19 publications

References 17 publications

Imaging Evidence of Diabetic Choroidopathy In Vivo: Angiographic Pathoanatomy and Choroidal-Enhanced Depth Imaging

Imaging Evidence of Diabetic Choroidopathy In Vivo: Angiographic Pathoanatomy and Choroidal-Enhanced Depth Imaging

Optical coherence tomography – current and future applications

Analysis of Morphological Features and Vascular Layers of Choroid in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography

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